Herbicidal sulfonamides

ABSTRACT

This invention relates to certain sulfonylurea compounds having a ring structure, which is attached ortho to the sulfonyl bridge through a double bond, agricultural compositions thereof and a method of their use as general preemergence and/or postemergence herbicides or plant growth regulants.

RELATED APPLICATION

This application is a continuation-in-part of copending application U.S. Ser. No. 740,894, filed June 3, 1985 now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to certain sulfonylurea compounds having a ring structure ortho to the sulfonyl bridge, agricultural compositions thereof and a method of use as general preemergence and/or postemergence herbicides or plant growth regulants.

New compounds effective for controlling the growth of undesired vegetation are in constant demand. In the most common situation, such compounds are sought to selectively control the growth of weeds in useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides which will control all plant growth are desired. Examples of areas in which complete control of all vegetation is desired are areas around fuel storage tanks, ammunition depots and industrial storage areas. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe.

U.S. Pat. No. 4,368,069 discloses herbicidal sulfonylureas of the formula ##STR1## wherein R is ##STR2## R₂ is C₂ -C₅ alkenyl, C₅ -C₆ cycloalkenyl or C₂ -C₃ alkenyl substituted with 1-3 Cl;

n is 0 or 1;

R₁ is, inter alia, H, F, Cl, Br;

R₅ and R₆ are independently H or CH₃ ; etc.

European Patent Application (EP-A) No. 106,512, published Apr. 25, 1984, discloses herbicidal sulfonylureas of the formula ##STR3## wherein R₁ is, in part, CH═CBr₂, CH═CHCO₂ CH₃, CH═CF₂ or CH═CHR₉ ;

R₉ is OCH₃ or OC₂ H₅ ;

R₂ is H, F, Cl, CH₃, OCH₃ or CF₃ ;

R₃ is H or CH₃ ; etc.

U.S. Pat. No. 4,460,401 discloses herbicidal sulfonylureas of the formula ##STR4## where, in part, Q is an optionally substituted ring such as ##STR5## etc; W' is O or S;

W is O or S;

R₁ is H, F, Cl, Br, CH₃, CF₃ or OCH₃ ;

R₁₃ is H or CH₃ ; etc.

U.S. Pat. No. 4,370,480 discloses herbicidal sulfonylureas of the formula ##STR6## where, in part, R₁ is ##STR7## R is H, C₁ -C₁₂ alkyl, C₂ -C₆ alkenyl, etc.; B is O or S(O)_(G) ;

G is 0 or 2;

T is O or ═NOR₁ ^(III) ;

R₂ is, inter alia, H, F, Cl, Br or C₁ -C₃ alkyl;

R₃ is H, F, Cl, Br or CH₃.

South African Patent Application No. 83/6449, published Mar. 1, 1984, discloses herbicidal sulfonylureas of the formula ##STR8## wherein R₁ is H, halogen, NO₂, NH₂, C₁ -C₅ alkyl, C₁ -C₄ haloalkyl or a QR₇, CO₂ R₈ or --(CO)_(n) NR₉ R₁₀ radical;

R₂ is, inter alia, H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy or C₁ -C₄ alkylthio;

R₃ is C₂ -C₁₀ alkenyl which is substituted by one or more fluorine or bromine atoms or by one or more hydroxyl, cyano, nitro, --(Y)_(m) CO(Z)_(n) R₈, --SO₂ NR₁₁ R₁₂, --S(O)_(p) --C₁ -C₃ haloalkyl or --S(O)_(n) --C₁ -C₃ alkyl groups, and which may additionally be substituted by one or more chlorine atoms;

X is O or S;

R₆ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy; etc.

SUMMARY OF THE INVENTION

Novel herbicidal compounds, agricultural compositions thereof and a method-of-use as general preemergence and/or postemergence herbicides or plant growth regulants have been found.

The novel compounds of the invention are compounds of the formula ##STR9## wherein J is ##STR10## R is H or CH₃ ; W is O or S;

R₁ is H, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, halogen, nitro, C₁ -C₃ alkoxy, SO₂ NR_(a) R_(b), C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, CO₂ R_(c), amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN;

R_(a) is H, C₁ -C₄ alkyl, C₂ -C₃ cyanoalkyl, OCH₃ or OC₂ H₅ ;

R_(b) is H, C₁ -C₄ alkyl or C₃ -C₄ alkenyl; or

R_(a) and R_(b) may be taken together as (CH₂)₃, (CH₂)₄, (CH₂)₅ or --CH₂ CH₂ OCH₂ CH₂ --;

R_(c) is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, C₂ -C₄ haloalkyl, C₂ -C₃ cyanoalkyl, C₅ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or C₂ -C₄ alkoxyalkyl;

R₂ is H, C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, phenyl, phenyl substituted with Cl, NO₂, CH₃ or OCH₃, C₁ -C₃ alkoxycarbonyl, C₁ -C₃ alkylsulfonyl or di(C₁ -C₂)alkylamino sulfamoyl;

Q is ##STR11## n is 0, 1 or 2; R₃ is H, C₁ -C₄ alkyl, Cl or Br;

R₁₀ is H or C₁ -C₄ alkyl;

E is a bridge of 4 or 5 atoms, which may be substituted or unsubstituted, containing 0-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, and also containing 2-5 carbon atoms, said bridge together with one carbon attachment site forming a partially saturated or a fully unsaturated, nonaromatic 5- or 6-membered carbocyclic or heterocyclic ring, with the proviso that when E contains two atoms of oxygen or sulfur, they must be separated by at least one atom of carbon, and that oxygen and sulfur are only linked to each other if the sulfur is in the form SO or SO₂ ; in the bridging group E, sulfur may take the form of S, SO or SO₂ and one or two of the carbon atoms may be a carbonyl, thiocarbonyl or the cyclic 5- and 6-membered ketals thereof; when one of the bridging atoms is a substituted carbon, the substituents on said carbon include H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, halogen, or C₁ -C₄ haloalkoxy; when the bridging atom is a nitrogen, the substituent on said nitrogen includes H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₁ -C₄ alkoxyalkyl, C₂ -C₄ cyanoalkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

A is ##STR12## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃)alkylamino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄ haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl, C₂ -C₅ alkylthioalkyl, ##STR13## W₁ and W₂ are independently O or S; m is 2 or 3;

R_(d) is H or CH₃ ;

R_(e) is C₁ -C₂ alkyl;

R_(f) is C₁ -C₂ alkyl;

Z is CH, N, CCH₃, CC₂ H₅, CCl or CBr;

Z₁ is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₂ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or CH₂ CH₃ ;

X₃ is CH₃ or OCH₃ ;

Y₃ is H or CH₃ ;

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl; and

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl;

and their agriculturally suitable salts; provided that

(a) when W is S, then R is H, A is A-1, Z is CH or N, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR14## (b) when X is Cl, Br, F or I, then Z is CH and Y is OCH₃, OC₂ H₅, NH₂, NHCH₃, N(CH₃)₂, OCF₂ H or N(OCH₃)CH₃ ;

(c) when X or Y is C₁ haloalkoxy, then Z is CH;

(d) when the bridging group E contains a thiocarbonyl substituent, said thiocarbonyl carbon must be bonded to a nitrogen atom;

(e) when J is J-2 or J-3, the substituent Q and the sulfonylurea bridge are on adjacent carbon atoms;

(f) when the total number of carbon atoms in X and Y is greater than 4, then the total number of carbon atoms in R₁, R₂ and Q is less than or equal to 10; and

(g) X₄ and Y₄ are not simultaneously Cl.

In the above definitions, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g. methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g. vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g. ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.

Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine and iodine.

Alkoxycarbonyl denotes methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl and isopropoxycarbonyl.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl, propylsulfonyl and isopropylsulfonyl.

Alkylthio, alkylsulfinyl, alkylamino, etc. are defined in an analogous manner.

In terms such as C₂ -C₃ alkylthioalkyl, the specified number of carbon atoms is meant to define the total number of carbon atoms in that substituent group. For example, C₂ -C₃ alkylthioalkyl would designate CH₂ SCH₃, CH₂ SC₂ H₅, CH₂ CH₂ SCH₃ or CH(CH₃)SCH₃, and C₂ -C₅ alkoxyalkoxy would represent OCH₂ OCH₃ through O(CH₂)₄ OCH₃ or OCH₂ O(CH₂)₃ CH₃ and the various structural isomers embraced therein. The term C₄ -C₇ cycloalkylalkyl is meant to represent a group which consists of a carbocyclic ring attached to an alkyl chain of at least one carbon atom wherein the total number of carbon atoms is between C₄ and C₇, inclusive.

The following compounds are preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy.

(1) Compounds of Formula I where W is O; R is H; Z is CH or N; and Q is ##STR15## W₃ is O or NR₆ ; W₄ is O, S, SO or SO₂ ;

R₄, R₅, R₆, R₇, R₈ and R₉ are independently H or C₁ -C₄ alkyl and R₁₀ is H or CH₃ ;

provided that the total number of carbon atoms of R₄, R₅, R₇, R₈ and R₉ is less than or equal to 4.

(2) Compounds of Preferred 1 where X is CH₃, OCH₃, OC₂ H₅, Cl, Br, F, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; and Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, CH₂ OC₂ H₅, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ SC₂ H₅, cyclopropyl, ##STR16## OCF₂ H, SCF₂ H, C.tbd.CH or C.tbd.CCH₃. (3) Compounds of Preferred 2 where R₁ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio.

(4) Compounds of Preferred 3 where R₄, R₅, R₆, R₇, R₈ and R₉ are independently H or CH₃ ; R₃ is H or C₁ -C₂ alkyl; and R₂ is H, C₁ -C₂ alkyl or CH₂ CH═CH₂.

(5) Compounds of Preferred 4 where A is A-1; X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃ ; Y is CH₃, OCH₃, C₂ H₅, CH₂ OCH₃, NHCH₃ or CH(OCH₃)₂ ; and Z is CH or N.

(6) Compounds of Preferred 5 where J is J-1 and R₁ is in the 5-position.

(7) Compounds of Preferred 5 where J is J-2 and R₁ is H.

(8) Compounds of Preferred 5 where J is J-3 and R₁ is H.

(9) Compounds of Preferred 5 where J is J-4 and R₁ is H.

(10) Compounds of Preferred 5 where J is J-5 and R₁ is H.

(11) Compounds of Preferred 6 where Q is Q-1.

(12) Compounds of Preferred 6 where Q is Q-2.

(13) Compounds of Preferred 6 where Q is Q-3.

(14) Compounds of Preferred 6 where Q is Q-4.

(15) Compounds of Preferred 6 where Q is Q-5.

(16) Compounds of Preferred 6 where Q is Q-6.

(17) Compounds of Preferred 6 where Q is Q-7.

(18) Compounds of Preferred 6 where Q is Q-8.

(19) Compounds of Preferred 6 where Q is Q-9.

(20) Compounds of Preferred 6 where Q is Q-10.

(21) Compounds of Preferred 6 where Q is Q-11.

(22) Compounds of Preferred 6 where Q is Q-12.

(23) Compounds of Preferred 6 where Q is Q-13.

(24) Compounds of Preferred 6 where Q is Q-14.

(25) Compounds of Preferred 6 where Q is Q-15.

(26) Compounds of Preferred 6 where Q is Q-16.

(27) Compounds of Preferred 6 where Q is Q-17.

(28) Compounds of Preferred 6 where Q is Q-18.

(29) Compounds of Preferred 6 where Q is Q-19.

(30) Compounds of Preferred 6 where Q is Q-20.

(31) Compounds of Preferred 6 where Q is Q-21.

(32) Compounds of preferred 6 where Q is Q-22.

(33) Compounds of Preferred 6 where Q is Q-23.

(34) Compounds of Preferred 6 where Q is Q-24.

(35) Compounds of Preferred 6 where Q is Q-25.

(36) Compounds of Preferred 6 where Q is Q-26.

(37) Compounds of Preferred 6 where Q is Q-27.

(38) Compounds of Preferred 6 where Q is Q-28.

(39) Compounds of Preferred 6 where Q is Q-29.

(40) Compounds of Preferred 6 where Q is Q-30.

(41) Compounds of Preferred 6 where Q is Q-31.

(42) Compounds of Preferred 6 where Q is Q-32.

(43) Compounds of Preferred 6 where Q is Q-33.

(44) Compounds of Preferred 6 where Q is Q-34.

(45) Compounds of Preferred 6 where Q is Q-35.

(46) Compounds of Preferred 6 where Q is Q-36.

(47) Compounds of Preferred 6 where Q is Q-37.

(48) Compounds of Preferred 6 where Q is Q-38.

(49) Compounds of Preferred 6 where Q is Q-39.

(50) Compounds of Preferred 6 where Q is Q-40.

(51) Compounds of Preferred 6 where Q is Q-41.

(52) Compounds of Preferred 6 where Q is Q-42.

(53) Compounds of Preferred 6 where Q is Q-43.

(54) Compounds of Preferred 6 where Q is Q-44.

(55) Compounds of Preferred 6 where Q is Q-45.

(56) Compounds of Preferred 6 where Q is Q-46.

(57) Compounds of Preferred 6 where Q is Q-47.

(58) Compounds of Preferred 6 where Q is Q-48.

(59) Compounds of Preferred 6 where Q is Q-49.

(60) Compounds of Preferred 6 where Q is Q-50.

(61) Compounds of Preferred 6 where Q is Q-51.

(62) Compounds of Preferred 6 where Q is Q-52.

(63) Compounds of Preferred 6 where Q is Q-53.

(64) Compounds of Preferred 6 where Q is Q-54.

(65) Compounds of Preferred 6 where Q is Q-55.

(66) Compounds of Preferred 6 where Q is Q-56.

(67) Compounds of Preferred 6 where Q is Q-57.

(68) Compounds of Preferred 6 where Q is Q-58.

(69) Compounds of Preferred 6 where Q is Q-59.

(70) Compounds of Preferred 6 where Q is Q-60.

(71) Compounds of Preferred 6 where Q is Q-61.

(72) Compounds of Preferred 6 where Q is Q-62.

(73) Compounds of Preferred 6 where Q is Q-63.

(74) Compounds of Preferred 6 where Q is Q-64.

(75) Compounds of Preferred 6 where Q is Q-65.

(76) Compounds of Preferred 6 where Q is Q-66.

(77) Compounds of Preferred 6 where Q is Q-67.

(78) Compounds of Preferred 6 where Q is Q-68.

(79) Compounds of Preferred 6 where Q is Q-69.

(80) Compounds of Preferred 6 where Q is Q-70.

(81) Compounds of Preferred 6 where Q is Q-71.

(82) Compounds of Preferred 6 where Q is Q-72.

(83) Compounds of Preferred 6 where Q is Q-73.

(84) Compounds of Preferred 6 where Q is Q-74.

(85) Compounds of Preferred 6 where Q is Q-75.

(86) Compounds of Preferred 6 where Q is Q-76.

(87) Compounds of Preferred 6 where Q is Q-77.

(88) Compounds of Preferred 6 where Q is Q-78.

(89) Compounds of Preferred 6 where Q is Q-79.

(90) Compounds of Preferred 6 where Q is Q-80.

(91) Compounds of Preferred 11 where W₃ is O.

(92) Compounds of Preferred 15 where W₃ is NH or NCH₃.

(93) Compounds of Preferred 17 where W₄ is S or SO₂.

(94) Compounds of Preferred 18 where W₄ is S or SO₂.

(95) Compounds of Preferred 26 where W₃ is O.

(96) Compounds of Preferred 32 where W₃ is NH or NCH₃.

(97) Compounds of Preferred 35 where W₄ is S or SO₂.

(98) Compounds of Preferred 36 where W₄ is S or SO₂.

(99) Compounds of Preferred 65 where W₃ is O.

(100) Compounds of Preferred 71 where W₃ is NH or NCH₃.

(101) Compounds of Preferred 72 where W₃ is NH or NCH₃.

(102) Compounds of Preferred 86 where W₃ is O.

(103) Compounds of Preferred 87 where W₃ is O.

Specifically Preferred for reasons of greatest ease of synthesis and/or greatest herbicidal efficacy are:

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-2-[(2-oxotetrahydro-3-furanylidene)methyl]benzenesulfonamide, m.p. 185°-190° C.; and

N-[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-[(2-oxotetrahydro-3-furanylidene)methyl]-3-chlorobenzenesulfonamide, m.p. 185°-190° C.(d).

DETAILED DESCRIPTION OF THE INVENTION Synthesis

Compounds of Formula I can be synthesized by one or more of the methods shown below in Equations 1, 2, and 3.

Equation 1 illustrates the reaction of sulfonyl isocyanates II with the appropriate heterocyclic amines of Formula III to give the desired sulfonylureas I. ##STR17## wherein J, R, W and A are as previously defined.

The reaction of Equation 1 is best carried out in an inert aprotic solvent such as methylene chloride, tetrahydrofuran or acetonitrile at a temperature between 0° and 82° C. A catalytic amount of 1,4-diazabicyclo[2,2,2]octane (DABCO) may be used to accelerate the reaction. In cases in which the products are insoluble in the reaction solvent, they may be isolated by simple filtration. When the products are soluble, they can be isolated by evaporation of the solvent and trituration of the residue with solvents such as 1-chlorobutane, diethyl ether or ethyl acetate, and filtration.

Compounds of Formula I can also be prepared as shown below in Equation 2 by treating sulfonamides of Formula IV with the methyl ester of a pyrimidine or triazine carbamic acid of Formula V in the presence of an equimolar quantity of trimethylaluminum. ##STR18## wherein J and A are as previously defined and W is O.

The reaction of Equation 2 is best carried out at temperatures between 25° and 83° C. in a solvent such as methylene chloride or 1,2-dichloroethane for 12 to 96 hours under an inert atmosphere, as taught in European Patent Application (EP-A) No. 83,975 (published July 20, 1983). The products of Formula I are conveniently isolated by acidifying the reaction solution with dilute aqueous hydrochloric acid, and extraction with a suitable solvent such as methylene chloride or ethyl acetate. If necessary, purification can be achieved by recrystallization or column chromatography. The methyl carbamates V can be synthesized by treatment of the corresponding heterocyclic amines of Formula III with dimethyl carbonate or methyl chloroformate in the presence of a base such as sodium hydride or pyridine.

Alternatively, compounds of Formula I can be prepared as shown below in Equation 3 by the reaction of sulfonamides IV with the phenyl ester of the appropriate carbamic acid, VI, in the presence of an equimolar quantity of a tertiary amine base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). ##STR19## wherein J and A are as previously defined and W is O.

The reaction shown in Equation 3 is best carried out at 25° C. in a solvent such as dioxane or acetonitrile for 1-2 hours under an inert atmosphere as described in European Patent Application No. 70,804 (published Jan. 26, 1983). The desired products of Formula I can be conveniently isolated by acidifying the reaction solution with aqueous hydrochloric acid. Alternatively, the aqueous layer can be extracted with a solvent such as methylene chloride or ethyl acetate. Drying and evaporation of the solvent affords the desired products. The phenyl carbamates VI can be synthesized by treatment of the corresponding heterocyclic amines of Formula III with diphenyl carbonate or phenyl chloroformate in the presence of a base such as sodium hydride, pyridine, or potassium carbonate with a catalytic amount of 4-dimethylaminopyridine. The mixture is stirred at temperatures between 25° and 65° C. in a suitable solvent such as tetrahydrofuran for 12-36 hours.

Sulfonyl isocyanates of Formula II can be prepared as shown in Equation 4 by the reaction of sulfonamides of the general structure IV with phosgene in the presence of n-butyl isocyanate and a catalytic amount of 1,4-diazabicyclo[2.2.2]octane (DABCO). ##STR20## wherein J is as previously defined and W is O.

The reaction depicted in Equation 4 is best carried out according to the procedure described in U.S. Pat. No. 4,238,621.

Alternatively, sulfonyl isocyanates II can be prepared via phosgenation of the preformed n-butylureas of Formula VII as represented in Equation 5. ##STR21## wherein J is as previously defined and W is O.

The compounds of Formula VII are conveniently prepared by stirring a mixture of the appropriate sulfonamide IV, anhydrous potassium carbonate, and n-butyl isocyanate in a suitable solvent such as acetone or methyl ethyl ketone at 25° to 80° C. until all of the isocyanate has reacted. The products are isolated by quenching in dilute aqueous acid and recrystallizing the insoluble solid. The n-butylureas VII are then treated with phosgene and a catalytic amount of DABCO in refuxing xylenes or chlorobenzene in a manner analogous to that described in the reference cited for Equation 4.

Another, somewhat milder, method for the preparation of sulfonyl isocyanates II is shown in Equation 6. Treatment of sulfonamides of Formula IV with thionyl chloride gives intermediate N-sulfinyl sulfonamides VIII, which afford sulfonyl isocyanates II upon exposure to phosgene in the presence of a catalytic amount of pyridine. ##STR22## wherein J is as previously defined and W is O.

The reaction of Equation 6 can best be performed according to the procedure of H. Ulrich, B. Tucker, and A. Sayigh, J. Org. Chem., 34, 3200 (1969).

Sulfonyl isothiocyanates (II, W is S) are known in the art and are prepared from the corresponding sulfonamides (IV) by reaction with carbon disulfide and potassium hydroxide followed by treatment of the resulting dipotassium salt VI with phosgene. Such a procedure is described in Arch. Pharm. 299, 174 (1966).

The required sulfonamides of Formula IV can be synthesized by one or both of the methods shown below in Equations 7 and 8.

Equation 7 depicts the reaction of sulfonyl chlorides of Formula IX with ammonia to give sulfonamides of Formula IV. ##STR23## wherein J is as previously defined.

The amination of Equation 7 is conveniently effected by adding at least two molar equivalents of either anhydrous ammonia or concentrated ammonium hydroxide to a solution of the sulfonyl chloride IX in a suitable solvent such as diethyl ether, tetrahydrofuran, or methylene chloride at temperatures between -30° and 25° C. The desired sulfonamides of Formula IV are isolated either by filtration, in which case the by-product ammonium chloride is removed by washing with water, or extraction into a suitable organic solvent such as methylene chloride or ethyl acetate. Drying and evaporation of the solvent then affords the products IV, which are usually sufficiently pure to be carried directly on to the next step.

Sulfonamides of Formula IV can also be prepared as shown in Equation 8 by treatment of the corresponding N-t-butylsulfonamides X with an appropriate acid such as trifluoroacetic (TFA), polyphosphoric (PPA), or p-toluenesulfonic acid (p-TSA). ##STR24## wherein J is as previously defined.

The reaction of Equation 8 is conveniently carried out by stirring a solution of the compound of Formula X in excess trifluoroacetic acid (approximately 0.3M) at about 25° C. for 1-24 hours. The desired sulfonamides of Formula IV are then isolated by removal of the volatiles in vacuo and crystallization from a suitable solvent such as diethyl ether, 1-chlorobutane, or ethyl acetate. Alternatively, the N-t-butylsulfonamides of Formula X can be treated with a catalytic amount of p-toluenesulfonic acid monohydrate in a solvent such as toluene or xylenes at reflux temperature for 1-6 hours. The desired products are then isolated in a manner analogous to the one described above. For use of polyphosphoric acid in the deprotection of N-t-butylsulfonamides, see J. G. Lombardino, J. Org. Chem., 36, 1843 (1971); for use of trifluoroacetic acid, see J. D. Catt and W. L. Matier, J. Org. Chem., 39, 566 (1974).

Sulfonyl chlorides of Formula IX can be prepared by one or more of the methods shown below in Equations 9, 10, and 11.

Diazotization of appropriately substituted aniline derivatives of Formula XI as shown in Equation 9, and subsequent coupling with sulfur dioxide in the presence of either cupric or cuprous chloride give the desired products of Formula IX. ##STR25## wherein J is as previously defined.

The reaction of Equation 9 can be effected by analogous methods described in EP-A Nos. 83,975 and 85,476 (published Aug. 10, 1983). In Equation 9, a substituted aniline XI in concentrated hydrochloric acid is treated with a solution of sodium nitrite in water at -5° to 5° C. After being stirred for 10-30 minutes at about 0° C., the solution is added to a mixture of excess sulfur dioxide and a catalytic amount of cupric or cuprous chloride in acetic acid at about 10° C. After stirring for 0.25 to 24 hours at temperatures between 10° to 25° C., the solution is poured into a large excess of ice water. The sulfonyl chlorides IX can be isolated by filtration, or by extraction into a solvent such as methylene chloride or diethyl ether, followed by drying and evaporation of the solvent.

Sulfonyl chlorides of Formula IX can also be prepared as shown below in Equation 10 by metal halogen exchange or directed lithiation of appropriately substituted aryl or heterocyclic substrates XII, and trapping with sulfuryl chloride. ##STR26## wherein J is as previously described.

The lithiation shown in Equation 10 can be performed according to the procedure of S. H. Bhattacharya, et al., J. Chem. Soc. (C), 1265 (1968) or by procedures reviewed by H. Gschwend and H. Rodriguez in Organic Reactions, Vol. 26, Wiley: New York, 1979.

Compounds of Formula IX can also be prepared via oxidative chlorination of the appropriate thioethers of Formula XIII as represented in Equation 11. ##STR27## wherein J is as previously defined; and R₁₂ is C₂ -C₄ alkyl or benzyl.

The reaction of Equation 11 can be carried out by treating a solution of the thioether XIII in a solvent such as acetic acid in the presence of at least 2.5 equivalents of water and at least 3.0 equivalents of chlorine at 0°-30° C. for 0.25 to 5 hours. The reaction is poured into ice water and the product is isolated by extraction with a suitable solvent such as methylene chloride, dried, and the solvent evaporated to yield a product sufficiently pure to be carried directly on to the next step.

The requisite aniline derivatives of Formula XI can be prepared by reduction of the corresponding nitro compounds of Formula XV as depicted in Equation 12. ##STR28## wherein J is as previously described.

The reduction reactions of Equation 12 can be accomplished by methods known in the literature by those skilled in the art. For details see, for example, EP-A No. 83,975.

The required thioethers of Formula XIII can be prepared by nucleophilic displacement of activated halo or nitro compounds of Formula XVI by the sodium or potassium salt of the appropriate mercaptan as depicted in Equation 13. ##STR29## wherein J is as previously defined; R₁₂ is C₂ -C₄ alkyl or benzyl; and M is Cl, Br or NO₂.

The reaction of Equation 13 can be accomplished by the addition of compounds of Formula XVI to a solution of the mercaptide salt, prepared by the action of a base such as sodium hydroxide or potassium t-butoxide on the corresponding mercaptan in dimethylformamide, at temperatures between 0° and 100° C. for 1 to 72 hours. The reaction mixture is poured into ice water and the product isolated by filtration or by extraction into a suitable solvent such as diethyl ether or methylene chloride followed by drying and evaporation of the solvent. If necessary, purification can be effected by recrystallization, vacuum distillation or chromatographic procedures.

The N-t-butylsulfonamides of Formula Xa can be synthesized by one or more of the methods shown below in Equations 14-21 which depict specific examples where J is J₁ but are also applicable to J₂ -J₅.

Direct carbon-carbon double bond formation can be achieved for the synthesis of sulfonamides of Formula Xa where R₃ ≠Cl or Br, as depicted in Equation 14, via the Wittig and related reactions such as the Horner. Wadsworth, Emmons olefination, and Peterson olefination reactions which are reviewed by H. O. House in Modern Synthetic Reactions, 2nd ed., W. A. Benjamin: Menlo Park, CA, 1972, pp. 682-709; W. Carruthers in Some Modern Methods of Organic Synthesis, 2nd ed., Cambridge: New York, 1978, pp. 106-127 and p. 318; and A. W. Johnson in Ylid Chemistry, Academic: London, 1966. In the Wittig reaction shown in Equation 14a, the phosphonium ylid XVIIIa can be reacted with sulfonamide XVII in a variety of organic solvents including benzene, methylene chloride, diethyl ether, tetrahydrofuran, acetonitrile, dimethylsulfoxide, and ethyl alcohol. The mixture is stirred at temperatures between 25° and 100° C. for 1-36 hours followed by aqueous workup and extraction with a solvent such as methylene chloride or diethyl ether. Drying and evaporation of the solvent affords the desired product. ##STR30## wherein R₁, R₃, and E are as previously defined except R₃ ≠Br, Cl.

Alternatively, sulfonamide XVII can be reacted with carbon nucleophiles of General Formula XVIIIb such as in the Aldol and related reactions, and with organometallic reagents such as alkyllithiums or Grignard reagents as depicted in Equation 14b. A general review of the additions of carbon nucleophiles to carbonyl compounds is available by C. D. Gutsche in The Chemistry of Carbonyl Compounds, Prentice Hall: Englewood Cliffs, NJ, 1967, pp. 71-99. For related examples, see also the previously mentioned H. O. House reference, pp. 629-682 and 817-818, and the W. Carruthers reference, pp. 52-71. Specific methods of formation and reactions of Grignard reagents can also be found in M. S. Kharasch and O. Reinmuth, Grignard Reactions of Non-Metallic Substances, Prentice Hall: Englewood Cliffs, NJ, 1954, pp. 5-91 and 138-528. The intermediate carbinol XIX can be dehydrated with a great variety of dehydrating agents to the unsaturated sulfonamide Xa. Acids such as sulfuric, oxalic, or phosphoric, bases such as potassium hydroxide, and other reagents such as phosphorous oxychloride or thionyl chloride can be used. For references to these procedures, see C. A. Buehler and D. E. Pearson in Survey of Organic Syntheses, Wiley: New York, 1970, p. 71. ##STR31## wherein R₁, R₃, and E are as previously defined except R₃ ≠Cl, Br.

The usual starting materals for the preparation of the phosphonium ylids XVIIIa and the carbon nucleophiles of Formula XVIIIb are shown in Equation 15. Compounds of Formula XVIIIc and XVIIId are believed to be either known in the art or capable of being prepared by those skilled in the art. Methods for their conversion to the phosphonium ylids or carbon nucleophiles can be found in the references cited in Equations 14a and 14b. ##STR32## wherein E is as previously defined; and

Br can be replaced by Cl or I.

Sulfonamides Xa can also be synthesized by the reaction of the dianions of either sulfonamide XX or XXI with an appropriately substituted carbonyl group such as XVIIIe or XVIIIf, respectively, as shown in Equation 16, followed by dehydration of the intermediate carbinols XIX or XXII as described in Equation 14b. The lithiations shown can be performed according to procedures reviewed by H. Rodriguez in Organic Reactions, Vol. 26, Wiley: New York, 1979, or according to the procedure of J. G. Lombardino, J. Org. Chem., 36, 1843 (1971). See also D. E. Butler and H. A. Dewald, J. Org. Chem., 36, 2542-2547 (1971) for a discussion of the metallation of substituted pyrazoles. ##STR33## wherein R₁, R₃, and E are as previously defined except R₃ ≠Cl, Br.

Carbonyl compounds of Formula XVIIIe and XVIIIf are either known in the art or are capable of being prepared by those skilled in the art.

The synthesis of sulfonamide XVIIb where R₃ =C₁ -C₄ alkyl is depicted in Equation 17. Aldehyde XVIIa, which exists mostly as its cyclic tautomer but nonetheless also undergoes the reactions described previously in Equations 14a and 14b, can be treated with a C₁ -C₄ alkyl organometallic reagent such as a Grignard or alkyllithium as described in Equation 14b, and the intermediate carbinol XXIII can be oxidized to the ketone XVIIb. A variety of oxidation procedures can be used, such as pyridinium chlorochromate as described by E. J. Corey and J. W. Suggs, Tetrahedron Lett., 2647 (1975); Swern-type oxidations as reviewed by K. Omura and D. Swern, Tetrahedron, 34, 1651 (1978); and Jones oxidation as described by M. J. Ashton et al. in J. Med. Chem., 27, 1245 (1984). ##STR34## wherein R₁ is as previously defined; and

R₃ is C₁ -C₄ alkyl.

Alternatively, as depicted in Equation 18, the intermediate carbinol XIXa from Equation 14b can also be oxidized as described above (if R₃ =H) to the corresponding ketone XXIV and then reacted with a C₁ -C₄ alkyllithium or Grignard reagent followed by dehydration of the intermediate tertiary carbinol XIXb to sulfonamide Xb. ##STR35## wherein R₁ and E are as previously defined; and

R₃ is as defined above.

Aldehyde XVIIa from Equation 17 can be synthesized utilizing the procedure described in Equation 16a by the addition of N,N-dimethylformamide (DMF) to the dianion of sulfonamide XX which affords XVIIa directly as shown in Equation 19. ##STR36## wherein R₁ is as previously defined.

The N-t-butylsulfonamides of Formula Xc, where n=1 or 2, can be prepared utilizing the intermediate aldehydes XVIIc and XVIId, respectively, as depicted in Equation 19b. The chemistry previously described in Equations 14a, 14b, 17 and 18 can also be applied to convert aldehydes XVIIc and XVIId to sulfonamides Xc. The aldehydes themselves can be prepared via the Wittig reaction (carried out either once or twice as shown) with sulfonamides XVIIa or XVIIb. ##STR37## wherein R₁, R₁₀ and E are as previously defined;

R₃ is H or C₁ -C₄ alkyl; and

n is 1 or 2.

The sulfonamides of Formula Xa where R₃ =Cl or Br can be synthesized as shown in Equation 20. For example, bromination of sulfonamide Xa where R₃ =H in a suitable solvent such as carbon tetrachloride or acetic acid provides the dibromo intermediate XXV which can dehydrohalogenate when treated with sodium acetate in refluxing ethyl alcohol to produce the desired sulfonamide XXVI. The halogenation and dehydrohalogenation can be carried out according to the procedures of N. H. Cromwell et al., in Organic Synthesis Collective Vol. III, Wiley: New York, 1955, pp. 105-108 and 125-127. ##STR38## wherein R₁ and E are as previously defined; and

R₃ is H.

The reactions described in Equation 20 may be applied to sulfonamide Xc (Equation 19b) when n is 1 or 2, provided that the olefinic bonds not containing R₃ (i.e. the --[CR₁₀ ═CH]_(n) bonds) are suitably protected beforehand by methods known in the art.

One skilled in the art will recognize that many of the procedures described in Equations 14, 16, 18, 19b, and 20 may result in the formation of two possible geometrical isomers about each carbon-carbon double bond, E or Z. This invention is meant to encompass all isomers. In cases where a mixture is obtained, the isomers can be separated by standard methods, such as fractional recrystallization or chromatography. Alternatively, the compounds can be used as a mixture of double bond isomers.

The chemistry described in Equations 14, 17, 18, 19b, and 20 can also be applied to substituted aromatic carbonyl compounds of Formula XXVII as shown in Equation 21. Further elaboration to sulfonamide IV can be carried out by one or more of the methods described in Equations 7-13. ##STR39## wherein R₃ is H, C₁ -C₄ alkyl;

B is Br, NO₂, SR₁₂ ;

R₁₂ is C₂ -C₄ alkyl or benzyl; and

R₁ is as previously defined.

A judicious choice of the appropriate methods for preparing compounds of Formulas I-XXVII can be made by those skilled in the art, taking into account the nature of the substituents contained within the J values (J₁ -J₅), namely Q and R₁, and their chemical compatibility with the reaction conditions of Equations 1-21.

The heterocyclic amines of Formula III in Equation 1 above can be prepared by methods known in the literature, or simple modifications thereof, by those skilled in the art. Where A is A-1, EP-A No. 84,224 (published July 27, 1983) describes methods for preparing aminopyrimidines and triazines substituted by acetal groups such as dialkoxymethyl or 1,3-dioxolan-2-yl, among other groups. Also, for example, South African Patent Application Nos. 82/5045 and 82/5671 describe methods for preparing aminopyrimidines and triazines substituted by haloalkyl or haloalkylthio groups such as OCH₂ CH₂ F, OCH₂ CF₃, SCF₂ H, or OCF₂ H, among other groups. South African Patent Application No. 83/7434 (published Oct. 5, 1983) describes methods for the synthesis of cyclopropylpyrimidines and triazines substituted by such groups as alkyl, haloalkyl, alkoxy, haloalkoxy, alkylamino, dialkylamino or alkoxyalkyl.

Compounds of Formula III, where A is A-2 or A-3, can be prepared by procedures disclosed in U.S. Pat. No. 4,339,267.

Compounds of Formula III, where A is A-4, can be prepared by methods taught in European Patent Application No. 46,677 (published Mar. 3, 1982).

Additional references dealing with the synthesis of bicyclic pyrimidines of Formula III, where A is A-2, A-3, or A-4 are Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc., 69, 3072 (1947); Mitler and Bhattachanya, Quart. J. Indian Chem. Soc., 4, 152 (1927); Shrage and Hitchings, J. Org. Chem., 16, 1153 (1951); Caldwell, Kornfeld and Donnell, J. Am. Chem. Soc., 63, 2188 (1941); and Fissekis, Myles and Brown, J. Org. Chem., 29, 2670 (1964).

Compounds of Formula III, where A is A-5, can be prepared by methods taught in U.S. Pat. No. 4,421,550.

Compounds of Formula III, where A is A-6, can be prepared by methods taught in European Patent Application No. 94,260 (published Nov. 16, 1983).

Compounds of Formula III, where A is A-7, can be prepared by methods taught in European Patent Application No. 125,864 (published Nov. 21, 1984).

In addition, general methods for preparing aminopyrimidines and triazines have been reviewed in the following publications;

"The Chemistry of Heterocyclic Compounds", a series published by Wiley-Interscience, Inc., New York and London;

"Pyrimidines", Vol. 16 of the same series by D. J. Brown, 1962;

"s-Triazines and Derivatives", Vol. 13 of the same series by E. M. Smolin and L. Rappoport, 1959; and

F. C. Schaefer, U.S. Pat. No. 3,154,547 and K. R. Huffman and F. C. Schaefer, J. Org. Chem. 28, 1812 (1963), which describes the synthesis of triazines.

Agriculturally suitable salts of compounds of Formula I are also useful herbicides and can be prepared in a number of ways known to the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide or carbonate). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contact of an aqueous solution of a salt of a compound of Formula I (e.g., alkali or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble, e.g., a potassium, sodium or calcium salt.

Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is further illustrated by the following specific examples. Temperatures are reported in degrees Celsius; abbreviations for nuclear magnetic resonance (NMR) are: s=singlet, d=doublet, t=triplet, m=multiplet, and peak positions are reported as parts per million downfield from internal tetramethylsilane. Infrared (IR) peak positions are given in reciprocal centimeters (cm⁻¹).

EXAMPLE 1 2-(1,1-Dimethylethyl)-2,3-dihydro-1,2-benzisothiazole-3-ol, 1,1-dioxide

To a stirred solution of 45.0 g (0.211 mol) of N-(1,1-dimethylethyl)benzenesulfonamide in 300 mL dry tetrahydrofuran cooled to 0°-10° under nitrogen was added dropwise 277.5 mL (0.444 mol) of 1.6 molar n-butyllithium maintaining the temperature below 20°.

The solution was stirred at room temperature for 2.5 hours during which time a thick precipitate formed. The slurry was cooled to 10°-20° and a solution of 49.1 mL (46.4 g, 0.635 mol) of dimethylformamide in 100-mL dry tetrahydrofuran was added dropwise. The reaction mixture was stirred at room temperature overnight, and was then poured into ice water and acidified with 1N aqueous hydrochloric acid. The layers were separated and the water layer extracted with ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, and evaporated to a yellow solid which was recrystallized (n-chlorobutane) to yield 41.7 g (82%) of the title compound: m.p. 114°-116°; IR (nujol) 3420, 1450, 1370, 1335, 1160, 1150, 1130 cm⁻¹ ; NMR (DMSO-d₆ 200 MHz) δ 1.51 (9H, s), 6.06 (1H, m), 6.8 (1H, m), 7.5-8.0 (4H, m).

EXAMPLE 2 N-(1,1-Dimethylethyl)-2-[(2-oxo-tetrahydro-3-furanylidene)methyl]benzenesulfonamide

To a stirred suspension of 6.0 g (0.025 mol) of the product of Example 1 in 100 mL methylene chloride was added 9.05 g (0.026 mol) of butyrolactonylidene triphenylphosphorane. The resulting clear solution was stirred at room temperature overnight, and was then poured into water, the layers were separated, and the aqueous layer was extracted with methylene chloride. The combined organic extracts were washed with brine, dried over magnesium sulfate and evaporated to a solid which was washed with hot chlorobutane to yield 6.7 g (87%) of the title compound: m.p. 173°-176°; IR (nujol) 3300, 1760, 1660, 1355, 1330, 1320, 1185, 1155, 1125 cm⁻¹ ; NMR (CDCl₃, 200 MHz) δ 1.21, (9H, s), 3.1 (2H, m), 4.4 (2H, t, J=7 Hz), 4.76 (NH, s), 7.4-7.7 (3H, m), 8.1-8.2 (2H, m).

EXAMPLE 3 2-[(2-oxotetrahydro-3-furanylidene)methyl] benzenesulfonamide

A solution of 5.0 g (0.016 mol) of the product of Example 2 in 70 mL trifluoroacetic acid was stirred at room temperature overnight and was then evaporated to yield 3.6 g (88%) of the title compound: m.p. 178°-180°; IR (nujol) 3330, 3230, 3220, 1720, 1640, 1340, 1160 cm⁻¹ ; NMR (DMSO-d₆, 200 MHz) δ 3.12 (2H, m), 4.36 (2H, t, J=7 Hz), 7.5-7.7 (3H, m), 7.93 (1H, m), 8.07 (1H, m).

EXAMPLE 4 N-[(4,6-Dimethoxypyrimidin-2-yl)-aminocarbonyl]-2-[(2-oxotetrahydro-3-furanylidene)methyl]benzenesulfonamide

To a stirred suspension of 0.09 g (0.0004 mol) of the product of Example 3 and 0.15 g (0.0005 mol) of (4,6-dimethoxy-2-pyrimidinyl)carbamic acid, phenyl ester in 1 mL dry acetonitrile under nitrogen was added dropwise 0.08 mL (0.08 g, 0.0005 mol) of 1,8-diazabicyclo[5.4.0]undec-7-ene. The mixture was stirred at room temperature for 30 min and was then diluted with water and acidified with 1N aqueous hydrochloric acid. The resulting precipitate was collected by filtration and washed well with water and ether to yield 0.1 g (64%) of the title compound: m.p. 185°-190° (gas evolution); IR (nujol) 3180 (br), 1755, 1740, 1710, 1700, 1610, 1560, 1355, 1165 cm⁻¹ ; NMR (CDCl₃, 200 MHz) δ 3.05 (2H, m), 4.29 (2H, t, J=7 Hz), 3.99 (6H, s), 5.83 (1H, s), 7.2 (NH, s), 7.4-7.8 (3H, m), 8.1 (1H, m), 8.12 (NH, s), 8.14 (1H, m).

EXAMPLE 5 4-Chloro-2-(1,1-dimethylethyl)-2,3-dihydro-1,2-benzisothiazole-3-ol, 1,1-dioxide

To a stirred solution of 23.0 g (0.093 mol) of 3-chloro-N-(1,1-dimethylethyl)benzenesulfonamide in 140 mL dry tetrahydrofuran cooled to 0° under nitrogen was added dropwise 122.4 mL (0.196 mol) of 1.6 molar n-butyllithium maintaining the temperature below 10°. The solution was stirred at 0°-10° for 15 min and then at room temperature for 1 hour. The mixture was cooled back to 0° and a solution of 21.6 mL (20.4 g, 0.280 mol) of dimethylformamide in 45 mL dry tetrahydrofuran was added dropwise. The reaction mixture was stirred at room temperature overnight, and was then poured into ice water and acidified with 3N aqueous hydrochloric acid. The layers were separated and the water layer extracted with ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, and evaporated to a yellow semi-solid which was washed with n-chlorobutane to yield 15.5 g (61%) of the title compound: m.p. 163° (dec); IR (nujol) 3280, 1370, 1140 cm⁻¹ ; NMR (CDCl₃, 200 MHz) δ 1.63 (9H, s), 3.1 (OH, d, J=10 Hz), 6.05 (1H, d, J=10 Hz), 7.4-7.7 (3H, m).

EXAMPLE 6 4-Chloro-N-(1,1-dimethylethyl)-2-[(2-oxotetrahydro-3-furanylidene)methyl]benzenesulfonamide

To a stirred solution of 5.5 g (0.020 mol) of the product of Example 5 in 100 mL methylene chloride was added 13.8 g (0.040 mol) of butyrolactonylidene triphenylphosphorane and the mixture was refluxed 24 hours. The mixture was cooled to room temperature and then poured into water. The layers were separated and the aqueous layer was extracted with methylene chloride. The combined organic extracts were washed with brine, dried over magnesium sulfate and evaporated to a solid which was purified by flash chromatography (2:1, petroleum ether:ethyl acetate) to yield 2.2 g (32%) of the title compound: m.p. 198°-201°; IR (nujol) 3230, 1760, 1330, 1150 cm⁻¹ ; NMR (CDCl₃, 200 MHz) δ 1.24 (9H, s), 2.8 (2H, m), 4.4 (2H, m), 7.3-8.1 (4H, m).

EXAMPLE 7 3-Chloro-2-[(2-oxotetrahydro-3-furanylidene)methyl]benzenesulfonamide

A solution of 2.1 g (0.0061 mol) of the product of Example 6 in 35 mL trifluoroacetic acid was stirred at room temperature overnight and was then evaporated to yield 1.4 g (80%) of the title compound: m.p. 172°-174°; IR (nujol) 3370, 3230, 1745, 1330, 1320, 1165, 1140 cm⁻¹ ; NMR (DMSO-d₆, 200 MHz) δ 2.64 (2H, m), 4.32 (2H, t, J=7 Hz), 7.4-7.9 (4H, m).

EXAMPLE 8 3-Chloro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-[(2-oxotetrahydro-3-furanylidene)methyl]benzenesulfonamide

To a stirred suspension of 0.15 g (0.0005 mol) of the product of Example 7 and 0.21 g (0.0008 mol) of (4,6-dimethoxy-2-pyrimidinyl)carbamic acid, phenyl ester in 1 mL dry acetonitrile under nitrogen was added dropwise 0.12 mL (0.12 g, 0.0008 mol) of 1,8-diazabicyclo[5.4.0]undec-7-ene. The mixture was stirred at room temperature for 1 hour and was then diluted with water and acidified with 1N aqueous hydrochloric acid. The resulting precipitate was collected by filtration and washed well with water and ether to yield 0.2 g (83%) of the title compound: m.p. 212°-216° (dec); IR (nujol) 3410, 1765, 1730, 1605, 1365, 1340, 1155 cm⁻¹ ; NMR (CDCl₃, 200 MHz) δ 2.7-2.8 (2H, m), 3.94 (6H, s), 4.1-4.2 (2H, m), 5.84 (1H, s), 7.2-7.8 (3H, m), 8.25 (1H, m).

Using the techniques described in Equations 1-21 and Examples 1-8, or simple modifications thereof, one skilled in the art can prepare the following compounds in Tables 1-22.

In Tables 1-22: R₃, R₄, R₅, R₆, R₇, R₈, R₉, and R₁₀ are independently H unless otherwise noted under Q values. ##STR40##

                                      TABLE 1                                      __________________________________________________________________________     General Formula 1                                                              Q       R  R.sub.1 R.sub.2                                                                          R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                __________________________________________________________________________     1       H  H         H  O   -- CH.sub.3 CH.sub.3                                                                             198-201                          1       H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             193-203                          1       H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            185-190                          1       CH.sub.3                                                                          H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       CH.sub.3                                                                          H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               1       H  H         CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  H         CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                               1       H  H         CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                               1       H  3-Cl      H  O   -- CH.sub.3 CH.sub.3                                                                             191-197                          1       H  3-Cl      H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             197-199                          1       H  3-Cl      H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            212-216                          1       H  3-Cl      H  O   -- Cl       OCH.sub.3                                                                            197-210                          1       CH.sub.3                                                                          3-Cl      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-CH.sub.3                                                                               H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-OCH.sub.2 CH.sub.3                                                                     H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-OCF.sub.2 H                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-NHCH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-N(CH.sub.3).sub.2                                                                      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-Cl      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-CF.sub.3                                                                               H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  6-SO.sub.2 N(CH.sub.3).sub.2                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  6-CO.sub.2 CH.sub.3                                                                      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1(R.sub.5 =CH.sub.3)                                                                   H  H         H  O   -- CH.sub.3 CH.sub.3                                                                             203-206                          1(R.sub.5 =CH.sub.3)                                                                   H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             201-203                          1(R.sub.5 =CH.sub.3)                                                                   H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            160-163                          1(R.sub.5 =CH.sub.3)                                                                   H  H         H  O   -- Cl       OCH.sub.3                                                                            180-183                          1       H  6-SO.sub.2 CH.sub.3                                                                      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1       H  H         H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                              1       H  H         H  O   -- CH.sub.2 F                                                                              OCH.sub.3                              1       H  H         H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                              1       H  H         H  O   -- CF.sub.3 OCH.sub.3                              1       H  H         H  O   -- SCH.sub.3                                                                               OCH.sub.3                              1       H  H         H  O   -- Cl       OCH.sub.3                                                                            206-210                          1       H  H         H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                     1       H  H         H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                              1       H  H         H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                              1       H  H         H  O   -- cyclopropyl                                                                             OCH.sub.3                              1       H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               1       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               1       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              1       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                     1       H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              1       H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              1       H  H         H  O   -- C.tbd.CH OCH.sub.3                              1       H  H         H  O   -- CHO      OCH.sub.3                              1       H  H         H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                        1       H  H         H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                            1       H  H         H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                            2       H  H         H  O   -- CH.sub.3 CH.sub.3                               2       H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               2       H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              2       H  H         H  O   -- Cl       OCH.sub.3                              2       H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              2       H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              2       H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               2       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               2       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              2       H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              2       H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              2       H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              3       H  H         H  --  -- CH.sub.3 CH.sub.3                                                                             186-188                          3       H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                                                                             145-150                          3       H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            146-155                          3       H  H         H  --  -- Cl       OCH.sub.3                                                                            192-194                          3       H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              3       H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              4       H  H         H  --  -- CH.sub.3 CH.sub.3                               4       H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               4       H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              4       H  H         H  --  -- Cl       OCH.sub.3                              4       H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              4       H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              5       H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               5       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               5       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              5       H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              5       H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              5       H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              5       H  H         H  O   -- CH.sub.3 CH.sub.3                               5       H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               5       H  H         H  O   -- OCH.sub. 3                                                                              OCH.sub.3                              5       H  H         H  O   -- Cl       OCH.sub.3                              5       H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              5       H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub. 3                             6       H  H         H  O   -- CH.sub.3 CH.sub.3                               6       H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               6       H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6       H  H         H  O   -- Cl       OCH.sub.3                              6       H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6       H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6       H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               6       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               6       H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              6       H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              6       H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              6       H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              7       H  H         H  --  S  CH.sub.3 CH.sub.3                               7       H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               7       H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              7       H  H         H  --  S  Cl       OCH.sub.3                              7       H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              7       H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              7       H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               7       H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               7       H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              7       H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              7       H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              7       H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              8       H  H         H  --  S  CH.sub.3 CH.sub.3                               8       H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               8       H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              8       H  H         H  --  S  Cl       OCH.sub.3                              8       H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              8       H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              8       H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               8       H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               8       H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              8       H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              8       H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              8       H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              9(R.sub. 6 =CH.sub.3)                                                                  H  H         H  --  -- CH.sub.3 CH.sub.3                               9(R.sub. 6 =CH.sub.3)                                                                  H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               9(R.sub. 6 =CH.sub.3)                                                                  H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              9(R.sub. 6 =CH.sub.3)                                                                  H  H         H  --  -- Cl       OCH.sub.3                              9(R.sub. 6 =CH.sub.3)                                                                  H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              9(R.sub. 6 =CH.sub.3)                                                                  H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              10      H  H         H  --  -- CH.sub.3 CH.sub.3                               10      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               10      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              10      H  H         H  --  -- Cl       OCH.sub.3                              10      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              10      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              11      H  H         H  --  O  CH.sub.3 CH.sub.3                               11      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               11      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              11      H  H         H  --  O  Cl       OCH.sub.3                              11      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              11      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              11      H  H         H  --  S  CH.sub.3 CH.sub.3                               11      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               11      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              11      H  H         H  --  S  Cl       OCH.sub.3                              11      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              11      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              12(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- CH.sub.3 CH.sub.3                               12(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               12(R.sub.6 =CH.sub.3)                                                                  H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              12(R.sub.6 =CH.sub.3)                                                                  H  H         H  --  -- Cl       OCH.sub.3                              12(R.sub. 6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              12(R.sub. 6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              13      H  H         H  --  S  CH.sub.3 CH.sub.3                               13      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               13      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              13      H  H         H  --  S  Cl       OCH.sub.3                              13      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              13      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              13      H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               13      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               13      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              13      H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              13      H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              13      H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              14      H  H         H  --  O  CH.sub.3 CH.sub.3                               14      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               14      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              14      H  H         H  --  O  Cl       OCH.sub.3                              14      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              14      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              15      H  H         H  --  -- CH.sub.3 CH.sub.3                               15      H  H         H  --  -- OCH.sub. 3                                                                              CH.sub.3                               15      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              15      H  H         H  --  -- Cl       OCH.sub.3                              15      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              15      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              16      H  H         H  O   -- CH.sub.3 CH.sub.3                               16      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               16      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      CH.sub.3                                                                          H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      CH.sub.3                                                                          H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               16      H  H         CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  H         CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                               16      H  H         CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                               16      H  3-Cl      H  O   -- CH.sub.3 CH.sub.3                               16      H  3-Cl      H  O   -- OCH.sub.3                                                                               CH.sub.3                               16      H  3-Cl      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  3-Cl      H  O   -- OCH.sub.3                                                                               Cl                                     16      CH.sub.3                                                                          3-Cl      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-CH.sub.3                                                                               H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-OCH.sub.2 CH.sub.3                                                                     H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-OCF.sub.2 H                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-NHCH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-N(CH.sub.3).sub.2                                                                      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-Cl      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-CF.sub.3                                                                               H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  6-CO.sub.2 CH.sub.3                                                                      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  6-SO.sub.2 CH.sub.3                                                                      H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16      H  H         H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                              16      H  H         H  O   -- CH.sub.2 F                                                                              OCH.sub.3                              16      H  H         H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                              16      H  H         H  O   -- CF 3     OCH.sub.3                              16      H  H         H  O   -- SCH.sub.3                                                                               OCH.sub.3                              16      H  H         H  O   -- Cl       OCH.sub.3                              16      H  H         H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                     16      H  H         H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                              16      H  H         H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                              16      H  H         H  O   -- cyclopropyl                                                                             OCH.sub.3                              16      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               16      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               16      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              16      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                     16      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              16      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              16      H  H         H  O   -- C.tbd.CH OCH.sub.3                              16      H  H         H  O   -- CHO      OCH.sub.3                              16      H  H         H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                        16      H  H         H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                            16      H  H         H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                            17      H  H         H  O   -- CH.sub.3 CH.sub.3                               17      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               17      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              17      H  H         H  O   -- Cl       OCH.sub.3                              17      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              17      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              17      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               17      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               17      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              17      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              17      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              17      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              18      H  H         H  O   -- CH.sub.3 CH.sub.3                               18      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               18      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              18      H  H         H  O   -- Cl       OCH.sub.3                              18      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              18      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              18      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               18      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               18      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              18      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              18      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              18      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              19      H  H         H  --  -- CH.sub.3 CH.sub.3                               19      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               19      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              19      H  H         H  --  -- Cl       OCH.sub.3                              19      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              19      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              20      H  H         H  --  -- CH.sub.3 CH.sub.3                               20      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               20      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              20      H  H         H  --  -- Cl       OCH.sub.3                              20      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              20      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              21      H  H         H  --  -- CH.sub.3 CH.sub.3                               21      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               21      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              21      H  H         H  --  -- Cl       OCH.sub. 3                             21      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              21      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              22      H  H         H  O   -- CH.sub.3 CH.sub.3                               22      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               22      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              22      H  H         H  O   -- Cl       OCH.sub.3                              22      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              22      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              22      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               22      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               22      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              22      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              22      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              22      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23      H  H         H  O   -- CH.sub.3 CH.sub.3                               23      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               23      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23      H  H         H  O   -- Cl       OCH.sub.3                              23      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               23      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               23      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              23      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              24      H  H         H  O   -- CH.sub.3 CH.sub.3                               24      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               24      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              24      H  H         H  O   -- Cl       OCH.sub.3                              24      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              24      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              24      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               24      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               24      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              24      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              24      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              24      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              25      H  H         H  --  S  CH.sub.3 CH.sub.3                               25      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               25      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              25      H  H         H  --  S  Cl       OCH.sub.3                              25      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              25      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              25      H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               25      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               25      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              25      H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              25      H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              25      H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              26      H  H         H  --  O  CH.sub.3 CH.sub.3                               26      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               26      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              26      H  H         H  --  O  Cl       OCH.sub.3                              26      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              26      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              26      H  H         H  --  S  CH.sub.3 CH.sub.3                               26      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               26      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              26      H  H         H  --  S  Cl       OCH.sub.3                              26      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              26      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27      H  H         H  --  O  CH.sub.3 CH.sub.3                               27      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               27      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              27      H  H         H  --  O  Cl       OCH.sub.3                              27      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              27      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              27      H  H         H  --  S  CH.sub.3 CH.sub.3                               27      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               27      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27      H  H         H  --  S  Cl       OCH.sub.3                              27      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27      H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               27      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               27      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              27      H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              27      H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              27      H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              28(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- CH.sub.3 CH.sub.3                               28(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               28(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              28(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- Cl       OCH.sub.3                              28(R.sub. 6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              28(R.sub. 6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              29(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- CH.sub.3 CH.sub.3                               29(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               29(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              29(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- Cl       OCH.sub.3                              29(R.sub. 6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              29(R.sub. 6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              30      H  H         H  --  -- CH.sub.3 CH.sub.3                               30      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               30      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              30      H  H         H  --  -- Cl       OCH.sub.3                              30      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              30      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              31      H  H         H  --  -- CH.sub.3 CH.sub.3                               31      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               31      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              31      H  H         H  --  -- Cl       OCH.sub.3                              31      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              31      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              32      H  H         H  --  -- CH.sub.3 CH.sub.3                               32      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               32      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              32      H  H         H  --  -- Cl       OCH.sub.3                              32      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              32      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              33      H  H         H  --  O  CH.sub.3 CH.sub.3                               33      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               33      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              33      H  H         H  --  O  Cl       OCH.sub.3                              33      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              33      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              33      H  H         H  --  S  CH.sub.3 CH.sub.3                               33      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               33      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              33      H  H         H  --  S  Cl       OCH.sub.3                              33      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              33      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              34      H  H         H  --  O  CH.sub.3 CH.sub.3                               34      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               34      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              34      H  H         H  --  O  Cl       OCH.sub.3                              34      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              34      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              35      H  H         H  --  O  CH.sub.3 CH.sub.3                               35      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               35      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              35      H  H         H  --  O  Cl       OCH.sub.3                              35      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              35      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              36      H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               36      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               36      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              36      H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              36      H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              36      H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              37      H  H         H  --  S  CH.sub.3 CH.sub.3                               37      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               37      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              37      H  H         H  --  S  Cl       OCH.sub.3                              37      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              37      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              38      H  H         H  --  O  CH.sub.3 CH.sub.3                               38      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               38      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              38      H  H         H  --  O  Cl       OCH.sub.3                              38      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              38      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              39(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- CH.sub.3 CH.sub.3                               39(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               39(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              39(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- Cl       OCH.sub.3                              39(R.sub. 6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              39(R.sub. 6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              40(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- CH.sub.3 CH.sub.3                               40(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               40(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              40(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- Cl       OCH.sub.3                              40(R.sub. 6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              40(R.sub. 6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              41(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- CH.sub.3 CH.sub.3                               41(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               41(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              41(R.sub. 6 =CH.sub.3)                                                                 H  H         H  --  -- Cl       OCH.sub.3                              41(R.sub. 6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              41(R.sub. 6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              42      H  H         H  --  -- CH.sub.3 CH.sub.3                               42      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               42      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              42      H  H         H  --  -- Cl       OCH.sub.3                              42      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              42      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              43      H  H         H  --  -- CH.sub.3 CH.sub.3                               43      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               43      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              43      H  H         H  --  -- Cl       OCH.sub.3                              43      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              43      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              44      H  H         H  --  -- CH.sub.3 CH.sub.3                               44      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               44      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              44      H  H         H  --  -- Cl       OCH.sub.3                              44      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              44      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              45      H  H         H  --  -- CH.sub.3 CH.sub.3                               45      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               45      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              45      H  H         H  --  -- Cl       OCH.sub.3                              45      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              45      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              46      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               46      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               46      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              46      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              46      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              46      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              47      H  H         H  --  O  CH.sub.3 CH.sub.3                               47      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               47      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              47      H  H         H  --  O  Cl       OCH.sub.3                              47      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              47      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              48      H  H         H  --  O  CH.sub.3 CH.sub.3                               48      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               48      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              48      H  H         H  --  O  Cl       OCH.sub.3                              48      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              48      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              49      H  H         H  --  O  CH.sub.3 CH.sub.3                               49      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               49      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              49      H  H         H  --  O  Cl       OCH.sub.3                              49      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              49      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              50      H  H         H  --  O  CH.sub.3 CH.sub.3                               50      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               50      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              50      H  H         H  --  O  Cl       OCH.sub.3                              50      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              50      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              51      H  H         H  --  S  CH.sub.3 CH.sub.3                               51      H  H         H  --  S  OCH.sub.3                                                                               CH.sub.3                               51      H  H         H  --  S  OCH.sub.3                                                                               OCH.sub.3                              51      H  H         H  --  S  Cl       OCH.sub.3                              51      H  5-OCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              51      H  5-SCH.sub.3                                                                              H  --  S  OCH.sub.3                                                                               OCH.sub.3                              52      H  H         H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               52      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               52      H  H         H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              52      H  H         H  --  SO.sub.2                                                                          Cl       OCH.sub.3                              52      H  5-OCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              52      H  5-SCH.sub.3                                                                              H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              53      H  H         H  --  -- CH.sub.3 CH.sub.3                               53      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               53      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              53      H  H         H  --  -- Cl       OCH.sub.3                              53      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              53      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              54      H  H         H  --  O  CH.sub.3 CH.sub.3                               54      H  H         H  --  O  OCH.sub.3                                                                               CH.sub.3                               54      H  H         H  --  O  OCH.sub.3                                                                               OCH.sub.3                              54      H  H         H  --  O  Cl       OCH.sub.3                              54      H  5-OCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              54      H  5-SCH.sub.3                                                                              H  --  O  OCH.sub.3                                                                               OCH.sub.3                              55      H  H         H  O   -- CH.sub.3 CH.sub.3                               55      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               55      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              55      H  H         H  O   -- Cl       OCH.sub.3                              55      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              55      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub. 3                             55      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               55      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               55      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              55      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              55      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              55      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              56      H  H         H  --  -- CH.sub.3 CH.sub.3                               56      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               56      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              56      H  H         H  --  -- Cl       OCH.sub.3                              56      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              56      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              57      H  H         H  O   -- CH.sub.3 CH.sub.3                               57      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               57      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              57      H  H         H  O   -- Cl       OCH.sub.3                              57      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              57      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              58      H  H         H  --  -- CH.sub.3 CH.sub.3                               58      H  H         H  --  -- OCH.sub.3                                                                               CH.sub.3                               58      H  H         H  --  -- OCH.sub.3                                                                               OCH.sub.3                              58      H  H         H  --  -- Cl       OCH.sub.3                              58      H  5-OCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              58      H  5-SCH.sub.3                                                                              H  --  -- OCH.sub.3                                                                               OCH.sub.3                              59      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               59      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               59      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              59      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              59      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              59      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              60      H  H         H  NCH.sub.3                                                                          -- CH.sub. 3                                                                               CH.sub.3                               60      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               60      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              60      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              60      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              60      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              61      H  H         H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               61      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               61      H  H         H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              61      H  H         H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                              61      H  5-OCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              61      H  5-SCH.sub.3                                                                              H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              62      H  H         H  O   -- CH.sub.3 CH.sub.3                               62      H  H         H  O   -- OCH.sub.3                                                                               CH.sub.3                               62      H  H         H  O   -- OCH.sub.3                                                                               OCH.sub.3                              62      H  H         H  O   -- Cl       OCH.sub.3                              62      H  5-OCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              62      H  5-SCH.sub.3                                                                              H  O   -- OCH.sub.3                                                                               OCH.sub.3                              63      H  H       H    --  O  CH.sub.3 CH.sub.3                               63      H  H       H    --  O  OCH.sub.3                                                                               CH.sub.3                               63      H  H       H    --  O  OCH.sub.3                                                                               OCH.sub.3                              63      H  H       H    --  O  Cl       OCH.sub.3                              63      H  5-OCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              63      H  5-SCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              63      H  H       H    --  S  CH.sub.3 CH.sub.3                               63      H  H       H    --  S  OCH.sub.3                                                                               CH.sub.3                               63      H  H       H    --  S  OCH.sub.3                                                                               OCH.sub.3                              63      H  H       H    --  S  Cl       OCH.sub.3                              63      H  5-OCH.sub.3                                                                            H    --  S  OCH.sub.3                                                                               OCH.sub.3                              63      H  5-SCH.sub.3                                                                            H    --  S  OCH.sub.3                                                                               OCH.sub.3                              64      H  H       H    --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                               64      H  H       H    --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               64      H  H       H    --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              64      H  H       H    --  SO.sub.2                                                                          Cl       OCH.sub.3                              64      H  5-OCH.sub.3                                                                            H    --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              64      H  5-SCH.sub.3                                                                            H    --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              64      H  H       H    --  O  CH.sub.3 CH.sub.3                               64      H  H       H    --  O  OCH.sub.3                                                                               CH.sub.3                               64      H  H       H    --  O  OCH.sub.3                                                                               OCH.sub.3                              64      H  H       H    --  O  Cl       OCH.sub.3                              64      H  5-OCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              64      H  5-SCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              65      H  H       H    --  -- CH.sub.3 CH.sub.3                               65      H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                               65      H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                              65      H  H       H    --  -- Cl       OCH.sub.3                              65      H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              65      H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              66      H  H       H    O   -- CH.sub.3 CH.sub.3                               66      H  H       H    O   -- OCH.sub.3                                                                               CH.sub.3                               66      H  H       H    O   -- OCH.sub.3                                                                               OCH.sub.3                              66      H  H       H    O   -- Cl       OCH.sub.3                              66      H  5-OCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              66      H  5-SCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              67      H  H       H    NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               67      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               67      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              67      H  H       H    NCH.sub.3                                                                          -- Cl       OCH.sub.3                              67      H  5-OCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              67      H  5-SCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              68      H  H       H    --  -- CH.sub.3 CH.sub.3                               68      H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                               68      H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                              68      H  H       H    --  -- Cl       OCH.sub. 3                             68      H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              68      H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              69      H  H       H    --  -- CH.sub.3 CH.sub.3                               69      H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                               69      H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                              69      H  H       H    --  -- Cl       OCH.sub.3                              69      H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              69      H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              70      H  H       H    O   -- CH.sub.3 CH.sub.3                               70      H  H       H    O   -- OCH.sub.3                                                                               CH.sub.3                               70      H  H       H    O   -- OCH.sub.3                                                                               OCH.sub.3                              70      H  H       H    O   -- Cl       OCH.sub.3                              70      H  5-OCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              70      H  5-SCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              71      H  H       H    NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               71      H  H       H    NCH.sub. 3                                                                         -- OCH.sub.3                                                                               CH.sub.3                               71      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              71      H  H       H    NCH.sub.3                                                                          -- Cl       OCH.sub.3                              71      H  5-OCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              71      H  5-SCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              72      H  H       H    NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               72      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               72      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              72      H  H       H    NCH.sub.3                                                                          -- Cl       OCH.sub.3                              72      H  5-OCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              72      H  5-SCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              73      H  H       H    NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               73      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               73      H  H       H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              73      H  H       H    NCH.sub.3                                                                          -- Cl       OCH.sub.3                              73      H  5-OCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              73      H  5-SCH.sub.3                                                                            H    NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              74      H  H       H    --  O  CH.sub.3 CH.sub.3                               74      H  H       H    --  O  OCH.sub.3                                                                               CH.sub.3                               74      H  H       H    --  O  OCH.sub.3                                                                               OCH.sub.3                              74      H  H       H    --  O  Cl       OCH.sub.3                              74      H  5-OCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              74      H  5-SCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              75      H  H       H    --  O  CH.sub.3 CH.sub.3                               75      H  H       H    --  O  OCH.sub.3                                                                               CH.sub.3                               75      H  H       H    --  O  OCH.sub.3                                                                               OCH.sub.3                              75      H  H       H    --  O  Cl       OCH.sub.3                              75      H  5-OCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              75      H  5-SCH.sub.3                                                                            H    --  O  OCH.sub.3                                                                               OCH.sub.3                              76      H  H       H    O   -- CH.sub.3 CH.sub.3                                                                             209-212                          76      H  H       H    O   -- OCH.sub.3                                                                               CH.sub.3                                                                             199-201                          76      H  H       H    O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            199-212                          76      H  H       H    O   -- Cl       OCH.sub.3                                                                            222-225                          76      H  5-OCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              76      H  5-SCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              77      H  H       H    O   -- CH.sub.3 CH.sub.3                               77      H  H       H    O   -- OCH.sub.3                                                                               CH.sub.3                                                                              97-104                          77      H  H       H    O   -- OCH.sub.3                                                                               OCH.sub.3                                                                             95-103                          77      H  H       H    O   -- Cl       OCH.sub.3                                                                             95-103                          77      H  5-OCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              77      H  5-SCH.sub.3                                                                            H    O   -- OCH.sub.3                                                                               OCH.sub.3                              78      H  H       H    --  -- CH.sub.3 CH.sub.3                               78      H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                               78      H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                              78      H  H       H    --  -- Cl       OCH.sub.3                              78      H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              78      H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              79      H  H       H    --  -- CH.sub.3 CH.sub.3                                                                             190-192                          79      H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                                                                             130-135                          79      H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            224-225                          79      H  H       H    --  -- Cl       OCH.sub.3                                                                            208-210                          79      H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              79      H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              79(R.sub.6 =CH.sub.3)                                                                  H  H       H    --  -- CH.sub.3 CH.sub.3                                                                             196-197                          79(R.sub.6 =CH.sub.3)                                                                  H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                                                                             197-198                          79(R.sub.6 =CH.sub.3)                                                                  H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            192-195                          79(R.sub.6 =CH.sub.3)                                                                  H  H       H    --  -- Cl       OCH.sub.3                                                                            159-165                          79(R.sub.6 =CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              79(R.sub.6 =CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H    --  -- CH.sub.3 CH.sub.3                               80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H    --  -- OCH.sub.3                                                                               CH.sub.3                               80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H    --  -- OCH.sub.3                                                                               OCH.sub.3                              80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H    --  -- Cl       OCH.sub.3                              80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  5-OCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  5-SCH.sub.3                                                                            H    --  -- OCH.sub.3                                                                               OCH.sub.3                              __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________     General Formula 2                                                              Q         R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                __________________________________________________________________________     1         H  H       H  O   -- CH.sub.3 CH.sub.3                               1         H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             188-193                          1         H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            188-191                          1         CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               1         H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                               1         H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                               1         H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                               1         H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             185-190                          1         H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            194-198                          1         H  3-Cl    H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             1         CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1 (R.sub.5 = CH.sub.3)                                                                   H  H       H  O   -- CH.sub.3 CH.sub.3                               1 (R.sub.5 = CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             188-190                          1 (R.sub.5 = CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            183-186                          1 (R.sub.5 = CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                                                           208-210                          1         H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              1         H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                              1         H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                              1         H  H       H  O   -- CF.sub.3 OCH.sub.3                              1         H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                              1         H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                   238-240                          1         H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                              1         H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                              1         H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                              1         H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               1         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               1         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              1         H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              1         H  H       H  O   -- C.tbd.CH OCH.sub.3                              1         H  H       H  O   -- CHO      OCH.sub.3                              1         H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                        1         H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                            1         H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                            2         H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              2         H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               2         CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               2         H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             2         H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              2         H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              2         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              2         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               2         CH.sub. 3                                                                         H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               2         H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             2         H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              2         H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              3         H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            160-166                          3         H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                                                             132-136                          3         CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               3         H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                                                           181-184                          3         H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              3         H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              4         H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              4         H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               4         CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               4         H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             4         H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              4         H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              5         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              5         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               5         CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               5         H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             5         H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              5         H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              5         H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              5         H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               5         CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               5         H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             5         H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              5         H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6         H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6         H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               6         CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               6         H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             6         H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6         H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              6         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              6         H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               6         CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               6         H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             6         H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              6         H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              7         H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              7         H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               7         CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               7         H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             7         H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              7         H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              7         H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              7         H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               7         CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               7         H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             7         H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              7         H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              8         H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              8         H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               8         CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               8         H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             8         H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              8         H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              8         H  H       H  --  SO.sub.2                                                                          CH.sub.3 OCH.sub.3                              8         H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               8         CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               8         H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             8         H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              8         H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              9 (R.sub.6 = CH.sub.3)                                                                   H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              9 (R.sub.6 = CH.sub.3)                                                                   H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               9 (R.sub.6 = CH.sub.3)                                                                   CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               9 (R.sub.6 = CH.sub.3)                                                                   H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             9 (R.sub.6 = CH.sub.3)                                                                   H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              9 (R.sub.6 = CH.sub.3)                                                                   H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              10        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              10        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               10        CH.sub.3                                                                          H       H  --  -- OCH.sub. 3                                                                              CH.sub.3                               10        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             10        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              10        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              11        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              11        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               11        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               11        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             11        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              11        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              11        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              11        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               11        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               11        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             11        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              11        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              12 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              12 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               12 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               12 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             12 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              12 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              13        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              13        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               13        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               13        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             13        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              13        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              13        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              13        H  H       H  --  SO.sub. 2                                                                         OCH.sub.3                                                                               CH.sub.3                               13        CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               13        H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             13        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              13        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              14        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              14        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               14        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               14        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             14        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              14        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              15        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              15        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               15        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               15        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             15        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              15        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              16        H  H       H  O   -- CH.sub.3 CH.sub.3                               16        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               16        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               16        H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                               16        H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                               16        H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                               16        H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                               16        H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                              16        H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                              16        H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                              16        H  H       H  O   -- CF.sub.3 OCH.sub.3                              16        H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                              16        H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                     16        H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                              16        H  H       H  O   -- OCH.sub.2 C.tbd.CH.sub.3                                                                OCH.sub.3                              16        H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                              16        H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                               16        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               16        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             16        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              16        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              16        H  H       H  O   -- C.tbd.CH.sub.3                                                                          OCH.sub.3                              16        H  H       H  O   -- CHO      OCH.sub.3                              16        H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                        16        H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                            16        H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                            17        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              17        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               17        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub. 3                              17        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             17        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              17        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              17        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              17        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               17        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               17        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             17        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              17        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              18        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              18        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               18        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               18        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             18        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              18        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              18        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              18        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               18        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               18        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             18        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              18        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              19        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              19        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               19        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               19        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             19        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              19        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              20        H  H       H  --  -- CH.sub.3 OCH.sub.3                              20        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               20        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               20        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             20        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              20        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              21        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              21        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               21        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               21        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             21        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              21        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              22        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              22        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               22        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               22        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             22        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              22        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               23        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               23        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               23        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               23        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             23        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              23        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               23        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               23        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             23        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              23        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub. 3                             24        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              24        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               24        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               24        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             24        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              24        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              24        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              24        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               24        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               24        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             24        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              24        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              25        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              25        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               25        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               25        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             25        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              25        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              25        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              25        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               25        CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               25        H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             25        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              25        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              26        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              26        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               26        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               26        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             26        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              26        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              26        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              26        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               26        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               26        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             26        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              26        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              27        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               27        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               27        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             27        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              27        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              27        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               27        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               27        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             27        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              27        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              27        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               27        CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               27        H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             27        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              27        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              28 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              28 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               28 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               28 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             28 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              28 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              29 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              29 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               29 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               29 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             29 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              29 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              30        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              30        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               30        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               30        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             30        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              30        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              31        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              31        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               31        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               31        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             31        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              31        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              32        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              32        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               32        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               32        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             32        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              32        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              33        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              33        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               33        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               33        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             33        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              33        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              33        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              33        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               33        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               33        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             33        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              33        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              34        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              34        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               34        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               34        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             34        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              34        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              35        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              35        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               35        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               35        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             35        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              35        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              36        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              36        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               36        CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               36        H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             36        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              36        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              37        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              37        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               37        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               37        H  H       H  --  S  OCH.sub.2 NH.sub.3                                                                      NHCH.sub.3                             37        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              37        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              38        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              38        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               38        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               38        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             38        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              38        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              39 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              39 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               39 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               39 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             39 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              39 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              40 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              40 (R.sub. 6 = CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               40 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               40 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             40 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              40 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              41 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              41 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               41 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               41 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             41 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              41 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              42        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              42        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               42        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               42        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             42        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              42        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              43        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              43        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               43        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               43        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             43        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              43        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              44        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              44        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               44        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               44        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             44        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              44        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              45        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              45        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               45        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               45        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             45        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              45        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              46        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              46        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               46        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               46        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             46        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              46        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              47        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              47        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               47        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               47        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             47        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              47        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              48        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              48        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               48        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               48        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             48        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              48        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              49        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              49        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               49        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               49        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             49        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              49        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              50        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              50        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               50        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               50        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             50        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              50        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              51        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              51        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               51        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               51        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             51        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              51        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              52        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              52        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub. 3                              52        CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               52        H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             52        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              52        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              53        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              53        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               53        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               53        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             53        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              53        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              54        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              54        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               54        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               54        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             54        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              54        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              55        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              55        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               55        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               55        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             55        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              55        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              55        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              55        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               55        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               55        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             55        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              55        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              56        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              56        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               56        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               56        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub. 3                            56        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              56        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              57        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              57        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               57        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               57        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             57        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              57        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              58        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              58        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              58        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               58        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             58        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              58        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              59        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              59        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               59        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               59        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             59        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              59        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              60        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              60        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               60        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               60        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             60        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              60        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              61        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              61        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               61        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               61        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             61        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              61        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              62        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              62        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               62        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               62        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             62        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              62        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              63        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              63        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               63        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               63        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             63        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              63        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              63        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                              63        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               63        CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                               63        H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             63        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              63        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                              64        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              64        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               64        CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                               64        H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             64        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              64        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                              64        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              64        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               64        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               64        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             64        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              64        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              65        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              65        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               65        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               65        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             65        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              65        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              66        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              66        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               66        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               66        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             66        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              66        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              67        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              67        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               67        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               67        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             67        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              67        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              68        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              68        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               68        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               68        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             68        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              68        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              69        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              69        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               69        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               69        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             69        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              69        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              70        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              70        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               70        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               70        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             70        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              70        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              71        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              71        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               71        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               71        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             71        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              71        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              72        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              72        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               72        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               72        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             72        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              72        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              73        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              73        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               73        CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                               73        H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             73        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              73        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                              74        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              74        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               74        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               74        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             74        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              74        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              75        H  H       H  --  O  OCH.sub.3                                                                               OCH.sub.3                              75        H  H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               75        CH.sub.3                                                                          H       H  --  O  OCH.sub.3                                                                               CH.sub.3                               75        H  H       H  --  O  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             75        H  5-OCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              75        H  5-SCH.sub.3                                                                            H  --  O  OCH.sub.3                                                                               OCH.sub.3                              76        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                                                            216-217                          76        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                                                             196-200                          76        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               76        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             76        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              76        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              77        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                              77        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               77        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                               77        H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             77        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              77        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                              78        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              78        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               78        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               78        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             78        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              78        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              79        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            >260                             79        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                                                             195-197                          79        CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               79        H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             79        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              79        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              79 (R.sub.6 = CH.sub.3 )                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            181-185                          79 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                                                             168-172                          79 (R.sub.6 = CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               79 (R.sub.6 = CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                                                           191-196                          79 (R.sub.6 = CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              79 (R.sub.6 = CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              80 (R.sub.4, R.sub.5 = CH.sub.3)                                                         H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                              80 (R.sub.4, R.sub.5 = CH.sub.3)                                                         H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               80 (R.sub.4, R.sub.5 = CH.sub.3)                                                         CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                               80 (R.sub.4, R.sub.5 = CH.sub.3)                                                         H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                             80 (R.sub.4, R.sub.5 = CH.sub.3)                                                         H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              80 (R.sub.4, R.sub.5 = CH.sub.3)                                                         H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                              __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________     General Formula 3                                                              Q      R R.sub.1 R.sub.3                                                                          W.sub.3                                                                            W.sub.4                                                                           X.sub.1                                                                              Y.sub.1                                                                           m.p.(°C.)                            __________________________________________________________________________      1     H H       H O   -- CH.sub.3                                                                             O                                              1      H H       H O   -- OCH.sub.3                                                                            O                                              1      H H       H O   -- CH.sub.3                                                                             CH.sub.2                                       1      H H       H O   -- OCH.sub.3                                                                            CH.sub.2                                       1      H 5-OCH.sub.3                                                                            H O   -- CH.sub.3                                                                             O                                              1      H 5-SCH.sub.3                                                                            H O   -- CH.sub.3                                                                             O                                              1      H 5-Cl    H O   -- CH.sub.3                                                                             O                                              1      H 5-CF.sub.3                                                                             H O   -- CH.sub.3                                                                             O                                              1      H 6-SO.sub.2 N(CH.sub.3).sub.2                                                           H O   -- CH.sub.3                                                                             O                                              1      H 6-CO.sub.2 CH.sub.3                                                                    H O   -- CH.sub.3                                                                             O                                              1      H 5-OCF.sub.2 H                                                                          H O   -- CH.sub.3                                                                             O                                              1      H H       H O   -- OCH.sub.2 CH.sub.3                                                                   CH.sub.2                                       1      H H       H O   -- OCF.sub.2 H                                                                          CH.sub.2                                       1      H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              1      H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            O                                              1      H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.2                                       1      H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       1      H 5-OCH.sub.3                                                                            H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              1      H 5-SCH.sub.3                                                                            H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              3      H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       3      H H       H --  -- CH.sub.3                                                                             O                                              3      H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       3      H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       3      H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       5      H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.2                                       5      H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              5      H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       5      H 5-OCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       5      H 5-SCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       7      H H       H --  S  CH.sub.3                                                                             CH.sub.2                                       7      H H       H --  S  CH.sub.3                                                                             O                                              7      H H       H --  S  OCH.sub.3                                                                            CH.sub.2                                       7      H 5-OCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       7      H 5-SCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       7      H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             CH.sub.2                                       7      H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             O                                              7      H H       H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       7      H 5-OCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       7      H 5-SCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       8      H H       H --  S  CH.sub.3                                                                             CH.sub.2                                       8      H H       H --  S  CH.sub.3                                                                             O                                              8      H H       H --  S  OCH.sub.3                                                                            CH.sub.2                                       8      H 5-OCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       8      H 5-SCH.sub.3                                                                            H --  S  OCH.sub. 3                                                                           CH.sub.2                                       8      H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             CH.sub.2                                       8      H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             O                                              8      H H       H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       8      H 5-OCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       8      H 5-SCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       16     H H       H O   -- CH.sub.3                                                                             O                                              16     H H       H O   -- OCH.sub.3                                                                            O                                              16     H H       H O   -- CH.sub.3                                                                             CH.sub.2                                       16     H H       H O   -- OCH.sub.3                                                                            CH.sub.2                                       16     H 5-OCH.sub.3                                                                            H O   -- CH.sub.3                                                                             O                                              16     H 5-SCH.sub.3                                                                            H O   -- CH.sub.3                                                                             O                                              16     H 5-Cl    H O   -- CH.sub.3                                                                             O                                              16     H 5-CF.sub.3                                                                             H O   -- CH.sub.3                                                                             O                                              16     H 6-SO.sub.2 N(CH.sub.3).sub.2                                                           H O   -- CH.sub.3                                                                             O                                              16     H 6-CO.sub.2 CH.sub.3                                                                    H O   -- CH.sub.3                                                                             O                                              16     H 5-OCF.sub.2 H                                                                          H O   -- CH.sub.3                                                                             O                                              16     H H       H O   -- OCH.sub.2 CH.sub.3                                                                   CH.sub.2                                       16     H H       H O   -- OCF.sub.2 H                                                                          CH.sub.2                                       19     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       19     H H       H --  -- CH.sub.3                                                                             O                                              19     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       19     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       19     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       20     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       20     H H       H --  -- CH.sub.3                                                                             O                                              20     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       20     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       20     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       21     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       21     H H       H --  -- CH.sub.3                                                                             O                                              21     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       21     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       21     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       22     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.2                                       22     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              22     H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       22     H 5-OCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       22     H 5-SCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       25     H H       H --  S  CH.sub.3                                                                             CH.sub.2                                       25     H H       H --  S  CH.sub.3                                                                             O                                              25     H H       H --  S  OCH.sub.3                                                                            CH.sub.2                                       25     H 5-OCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       25     H 5-SCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       25     H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             CH.sub.2                                       25     H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             O                                              25     H H       H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       25     H 5-OCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       25     H 5-SCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       26     H H       H --  S  CH.sub.3                                                                             CH.sub.2                                       26     H H       H --  S  CH.sub.3                                                                             O                                              26     H H       H --  S  OCH.sub.3                                                                            CH.sub.2                                       26     H 5-OCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       26     H 5-SCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       26     H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             CH.sub.2                                       26     H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             O                                              26     H H       H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       26     H 5-OCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       26     H 5-SCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       27     H H       H --  S  CH.sub.3                                                                             CH.sub.2                                       27     H H       H --  S  CH.sub.3                                                                             O                                              27     H H       H --  S  OCH.sub.3                                                                            CH.sub.2                                       27     H 5-OCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       27     H 5-SCH.sub.3                                                                            H --  S  OCH.sub.3                                                                            CH.sub.2                                       27     H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             CH.sub.2                                       27     H H       H --  SO.sub.2                                                                          CH.sub.3                                                                             O                                              27     H H       H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub. 2                                      27     H 5-OCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       27     H 5-SCH.sub.3                                                                            H --  SO.sub.2                                                                          OCH.sub.3                                                                            CH.sub.2                                       29(R.sub. 6 =CH.sub.3)                                                                H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       29(R.sub. 6 =CH.sub.3)                                                                H H       H --  -- CH.sub.3                                                                             O                                              29(R.sub. 6 =CH.sub.3)                                                                H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       29(R.sub. 6 =CH.sub.3)                                                                H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       29(R.sub. 6 =CH.sub.3)                                                                H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       55     H H       H O   -- CH.sub.3                                                                             CH.sub.2                                       55     H H       H O   -- CH.sub.3                                                                             O                                              55     H H       H O   -- OCH.sub.3                                                                            CH.sub.2                                       55     H 5-OCH.sub.3                                                                            H O   -- OCH.sub.3                                                                            CH.sub.2                                       55     H 5-SCH.sub.3                                                                            H O   -- OCH.sub.3                                                                            CH.sub.2                                       55     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.2                                       55     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              55     H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       55     H 5-OCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       55     H 5-SCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       56     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       56     H H       H --  -- CH.sub.3                                                                             O                                              56     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       56     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       56     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       61     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.2                                       61     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              61     H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       61     H 5-OCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       61     H 5-SCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       62     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.2                                       62     H H       H NCH.sub.3                                                                          -- CH.sub.3                                                                             O                                              62     H H       H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       62     H 5-OCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       62     H 5-SCH.sub.3                                                                            H NCH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.2                                       65     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       65     H H       H --  -- CH.sub.3                                                                             O                                              65     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       65     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       65     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       68     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       68     H H       H --  -- CH.sub.3                                                                             O                                              68     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       68     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       68     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       76     H H       H O   -- CH.sub.3                                                                             CH.sub.2                                       76     H H       H O   -- CH.sub.3                                                                             O                                              76     H H       H O   -- OCH.sub.3                                                                            CH.sub.2                                       76     H 5-OCH.sub.3                                                                            H O   -- OCH.sub.3                                                                            CH.sub.2                                       76     H 5-SCH.sub.3                                                                            H O   -- OCH.sub.3                                                                            CH.sub.2                                       78     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       78     H H       H --  -- CH.sub.3                                                                             O                                              78     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       78     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       78     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       79     H H       H --  -- CH.sub.3                                                                             CH.sub.2                                       79     H H       H --  -- CH.sub.3                                                                             O                                              79     H H       H --  -- OCH.sub.3                                                                            CH.sub.2                                       79     H 5-OCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       79     H 5-SCH.sub.3                                                                            H --  -- OCH.sub.3                                                                            CH.sub.2                                       __________________________________________________________________________

                  TABLE 4                                                          ______________________________________                                         General Formula 4                                                                                                            m.p.                             Q        R     R.sub.1  R.sub.3                                                                             W.sub.3                                                                              W.sub.4                                                                             X.sub.1                                                                              (°C.)                     ______________________________________                                          1       H     H        H    O     --   CH.sub.3                               1        H     H        H    O     --   OCH.sub.3                              1        H     5-OCH.sub.3                                                                             H    O     --   CH.sub.3                               1        H     5-SCH.sub.3                                                                             H    O     --   CH.sub.3                               3        H     H        H    --    --   CH.sub.3                               3        H     H        H    --    --   OCH.sub.3                              3        H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               3        H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               5        H     H        H    NCH.sub.3                                                                            --   CH.sub.3                               5        H     H        H    NCH.sub.3                                                                            --   OCH.sub.3                              5        H     5-OCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               5        H     5-SCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               7        H     H        H    --    S    CH.sub.3                               7        H     H        H    --    S    OCH.sub.3                              7        H     5-OCH.sub.3                                                                             H    --    S    CH.sub.3                               7        H     5-SCH.sub.3                                                                             H    --    S    CH.sub.3                               7        H     H        H    --    SO.sub.2                                                                            CH.sub.3                               7        H     H        H    --    SO.sub.2                                                                            OCH.sub.3                              7        H     5-OCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               7        H     5-SCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               8        H     H        H    --    S    CH.sub.3                               8        H     H        H    --    S    OCH.sub.3                              8        H     5-OCH.sub.3                                                                             H    --    S    CH.sub.3                               8        H     5-SCH.sub.3                                                                             H    --    S    CH.sub.3                               8        H     H        H    --    SO.sub.2                                                                            CH.sub.3                               8        H     H        H    --    SO.sub.2                                                                            OCH.sub.3                              8        H     5-OCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               8        H     5-SCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               16       H     H        H    --    --   CH.sub.3                               16       H     H        H    --    --   OCH.sub.3                              16       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               16       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               19       H     H        H    --    --   CH.sub.3                               19       H     H        H    --    --   OCH.sub.3                              19       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               19       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               20       H     H        H    --    --   CH.sub.3                               20       H     H        H    --    --   OCH.sub.3                              20       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               20       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               21       H     H        H    --    --   CH.sub.3                               21       H     H        H    --    --   OCH.sub.3                              21       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               21       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               22       H     H        H    NCH.sub.3                                                                            --   CH.sub.3                               22       H     H        H    NCH.sub.3                                                                            --   OCH.sub.3                              22       H     5-OCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               22       H     5-SCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               25       H     H        H    --    S    CH.sub.3                               25       H     H        H    --    S    OCH.sub.3                              25       H     5-OCH.sub.3                                                                             H    --    S    CH.sub.3                               25       H     5-SCH.sub.3                                                                             H    --    S    CH.sub.3                               25       H     H        H    --    SO.sub.2                                                                            CH.sub.3                               25       H     H        H    --    SO.sub.2                                                                            OCH.sub.3                              25       H     5-OCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               25       H     5-SCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               26       H     H        H    --    S    CH.sub.3                               26       H     H        H    --    S    OCH.sub.3                              26       H     5-OCH.sub.3                                                                             H    --    S    CH.sub.3                               26       H     5-SCH.sub.3                                                                             H    --    S    CH.sub.3                               26       H     H        H    --    SO.sub.2                                                                            CH.sub.3                               26       H     H        H    --    SO.sub.2                                                                            OCH.sub.3                              26       H     5-OCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               26       H     5-SCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               27       H     H        H    --    S    CH.sub.3                               27       H     H        H    --    S    OCH.sub.3                              27       H     5-OCH.sub.3                                                                             H    --    S    CH.sub.3                               27       H     5-SCH.sub.3                                                                             H    --    S    CH.sub.3                               27       H     H        H    --    SO.sub.2                                                                            CH.sub.3                               27       H     H        H    --    SO.sub.2                                                                            OCH.sub.3                              27       H     5-OCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               27       H     5-SCH.sub.3                                                                             H    --    SO.sub.2                                                                            CH.sub.3                               29 (R.sub.6 =CH.sub.3)                                                                  H     H        H    --    --   CH.sub.3                               29 (R.sub.6 =CH.sub.3)                                                                  H     H        H    --    --   OCH.sub.3                              29 (R.sub.6 =CH.sub.3)                                                                  H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               29 (R.sub.6 =CH.sub.3)                                                                  H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               55       H     H        H    O     --   CH.sub.3                               55       H     H        H    O     --   OCH.sub.3                              55       H     5-OCH.sub.3                                                                             H    O     --   CH.sub.3                               55       H     5-SCH.sub.3                                                                             H    O     --   CH.sub.3                               55       H     H        H    NCH.sub.3                                                                            --   CH.sub.3                               55       H     H        H    NCH.sub.3                                                                            --   OCH.sub.3                              55       H     5-OCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               55       H     5-SCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               56       H     H        H    --    --   CH.sub.3                               56       H     H        H    --    --   OCH.sub.3                              56       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               56       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               61       H     H        H    NCH.sub. 3                                                                           --   CH.sub.3                               61       H     H        H    NCH.sub.3                                                                            --   OCH.sub.3                              61       H     5-OCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               61       H     5-SCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               62       H     H        H    NCH.sub.3                                                                            --   CH.sub.3                               62       H     H        H    NCH.sub.3                                                                            --   OCH.sub.3                              62       H     5-OCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               62       H     5-SCH.sub.3                                                                             H    NCH.sub.3                                                                            --   CH.sub.3                               65       H     H        H    --    --   CH.sub.3                               65       H     H        H    --    --   OCH.sub.3                              65       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               65       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               68       H     H        H    --    --   CH.sub.3                               68       H     H        H    --    --   OCH.sub.3                              68       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               68       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               76       H     H        H    O     --   CH.sub.3                               76       H     H        H    O     --   OCH.sub.3                              76       H     5-OCH.sub.3                                                                             H    O     --   CH.sub.3                               76       H     5-SCH.sub.3                                                                             H    O     --   CH.sub. 3                              78       H     H        H    --    --   CH.sub.3                               78       H     H        H    --    --   OCH.sub.3                              78       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               78       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               79       H     H        H    --    --   CH.sub.3                               79       H     H        H    --    --   OCH.sub.3                              79       H     5-OCH.sub.3                                                                             H    --    --   CH.sub.3                               79       H     5-SCH.sub.3                                                                             H    --    --   CH.sub.3                               ______________________________________                                    

                                      TABLE 5                                      __________________________________________________________________________     General Formula 5                                                              Q      R R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X.sub.1                                                                             Y.sub.3                                                                           m.p. (°C.)                           __________________________________________________________________________      1     H H       H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H H       H  O   -- CH.sub.3                                                                            H                                              1      H H       H  O   -- OCH.sub.3                                                                           CH.sub.3                                       1      H H       H  O   -- OCH.sub.3                                                                           H                                              1      H H       H  O   -- OCF.sub.2 H                                                                         CH.sub.3                                       1      H 5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                           H                                              1      H 5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                           H                                              1      H 5-Cl    H  O   -- OCH.sub.3                                                                           H                                              1      H 5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                           H                                              1      H 5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                           H                                              1      H 6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                           H                                              1      H 6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                           H                                              1      H 5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                           H                                              1      H 5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                           H                                              1      H 5-SCH.sub.3                                                                            CH.sub.3                                                                          O   -- OCH.sub.3                                                                           H                                              3      H H       H  --  -- OCH.sub.3                                                                           H                                              3      H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              3      H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              5      H H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              5      H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              5      H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              7      H H       H  --  S  OCH.sub.3                                                                           H                                              7      H 5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              7      H 5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              7      H H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              7      H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              7      H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub. 3                                                                          H                                              8      H H       H  --  S  OCH.sub.3                                                                           H                                              8      H 5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              8      H 5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              16     H H       H  --  -- OCH.sub.3                                                                           H                                              16     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              16     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              19     H H       H  --  -- OCH.sub.3                                                                           H                                              19     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              19     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              20     H H       H  --  -- OCH.sub.3                                                                           H                                              20     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              20     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              21     H H       H  --  -- OCH.sub.3                                                                           H                                              21     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              21     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              22     H H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              22     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              22     H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              25     H H       H  --  S  OCH.sub.3                                                                           H                                              25     H 5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              25     H 5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              25     H H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              25     H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              25     H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              26     H H       H  --  S  OCH.sub.3                                                                           H                                              26     H 5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              26     H 5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              26     H H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              26     H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              26     H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              27     H H       H  --  S  OCH.sub.3                                                                           H                                              27     H 5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              27     H 5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                           H                                              27     H H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              27     H 5-OCH.sub.3                                                                            H  --  SO.sub. 2                                                                         OCH.sub.3                                                                           H                                              27     H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                           H                                              29 (R.sub.6 =CH.sub.3)                                                                H H       H  --  -- OCH.sub.3                                                                           H                                              29 (R.sub.6 =CH.sub.3)                                                                H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              29 (R.sub.6 =CH.sub.3)                                                                H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              55     H H       H  O   -- OCH.sub.3                                                                           H                                              55     H 5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                           H                                              55     H 5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                           H                                              55     H H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              55     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              55     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              56     H H       H  --  -- OCH.sub.3                                                                           H                                              56     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              56     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              61     H H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              61     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              61     H 5-SCH.sub.3                                                                            H  NCH.sub. 3                                                                         -- OCH.sub.3                                                                           H                                              62     H H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              62     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              62     H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           H                                              65     H H       H  --  -- OCH.sub.3                                                                           H                                              65     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              65     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              68     H H       H  --  -- OCH.sub.3                                                                           H                                              68     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              68     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              76     H H       H  O   -- OCH.sub.3                                                                           H                                              76     H 5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                           H                                              76     H 5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                           H                                              78     H H       H  --  -- OCH.sub.3                                                                           H                                              78     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              78     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              79     H H       H  --  -- OCH.sub.3                                                                           H                                              79     H 5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              79     H 5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                           H                                              __________________________________________________________________________

                                      TABLE 6                                      __________________________________________________________________________     General Formula 6                                                              Q      R R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X.sub.2                                                                             Y.sub.2                                                                            m.p. (°C.)                          __________________________________________________________________________     1      H H       H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H H       H  O   -- CH.sub.3                                                                            OCH.sub.3                                      1      H H       H  O   -- CH.sub.3                                                                            SCH.sub.3                                      1      H H       H  O   -- CH.sub.2 CF.sub.3                                                                   CH.sub.3                                       1      H H       H  O   -- CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                      1      H H       H  O   -- CH.sub.2 CF.sub.3                                                                   SCH.sub.3                                      1      H 5-OCH.sub.3                                                                            H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 5-SCH.sub.3                                                                            H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 5-Cl    H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 5-OCF.sub.2 H                                                                          H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 6-CO.sub.2 CH.sub.3                                                                    H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 5-NHCH.sub.3                                                                           H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 5-N(CH.sub.3).sub.2                                                                    H  O   -- CH.sub.3                                                                            CH.sub.3                                       1      H 5-SCH.sub.3                                                                            CH.sub.3                                                                          O   -- CH.sub.3                                                                            CH.sub.3                                       1      H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            CH.sub.3                                       1      H H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                           CH.sub.3                                       1      H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            SCH.sub.3                                      3      H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       3      H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      3      H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      3      H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      5      H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            CH.sub.3                                       5      H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      5      H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      5      H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      7      H H       H  --  S  CH.sub.3                                                                            CH.sub.3                                       7      H H       H  --  S  CH.sub.3                                                                            OCH.sub.3                                      7      H 5-OCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      7      H 5-SCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      7      H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            CH.sub.3                                       7      H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      7      H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      7      H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      8      H H       H  --  S  CH.sub.3                                                                            CH.sub.3                                       8      H H       H  --  S  CH.sub.3                                                                            OCH.sub.3                                      8      H 5-OCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      8      H 5-SCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      8      H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            CH.sub.3                                       8      H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      8      H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      8      H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      16     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       16     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      16     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      16     H 5-SCH.sub. 3                                                                           H  --  -- CH.sub.3                                                                            OCH.sub.3                                      19     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       19     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      19     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      19     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      20     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       20     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      20     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      20     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      21     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       21     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      21     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      22     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            CH.sub.3                                       22     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      22     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      22     H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      25     H H       H  --  S  CH.sub.3                                                                            CH.sub.3                                       25     H H       H  --  S  CH.sub.3                                                                            OCH.sub.3                                      25     H 5-OCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      25     H 5-SCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      25     H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            CH.sub.3                                       25     H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      25     H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      25     H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      26     H H       H  --  S  CH.sub.3                                                                            CH.sub.3                                       26     H H       H  --  S  CH.sub.3                                                                            OCH.sub.3                                      26     H 5-OCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      26     H 5-SCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      26     H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            CH.sub.3                                       26     H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      26     H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      26     H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      27     H H       H  --  S  CH.sub.3                                                                            CH.sub. 3                                      27     H H       H  --  S  CH.sub.3                                                                            OCH.sub.3                                      27     H 5-OCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      27     H 5-SCH.sub.3                                                                            H  --  S  CH.sub.3                                                                            OCH.sub.3                                      27     H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            CH.sub.3                                       27     H H       H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      27     H 5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      27     H 5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                      29 (R.sub.6 =CH.sub.3)                                                                H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       29 (R.sub.6 =CH.sub.3)                                                                H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      29 (R.sub.6 =CH.sub.3)                                                                H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      29 (R.sub.6 =CH.sub.3)                                                                H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      55     H H       H  O   -- CH.sub.3                                                                            CH.sub.3                                       55     H H       H  O   -- CH.sub.3                                                                            OCH.sub.3                                      55     H 5-OCH.sub.3                                                                            H  O   -- CH.sub.3                                                                            OCH.sub.3                                      55     H 5-SCH.sub.3                                                                            H  O   -- CH.sub.3                                                                            OCH.sub.3                                      55     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            CH.sub.3                                       55     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      55     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      55     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      56     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       56     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      56     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      56     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      61     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            CH.sub.3                                       61     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      61     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      61     H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      62     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            CH.sub.3                                       62     H H       H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      62     H 5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      62     H 5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- CH.sub.3                                                                            OCH.sub.3                                      65     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       65     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      65     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      65     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      68     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       68     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      68     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      68     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      76     H H       H  O   -- CH.sub.3                                                                            CH.sub.3                                       76     H H       H  O   -- CH.sub.3                                                                            OCH.sub.3                                      76     H 5-OCH.sub.3                                                                            H  O   -- CH.sub.3                                                                            OCH.sub.3                                      76     H 5-SCH.sub.3                                                                            H  O   -- CH.sub.3                                                                            OCH.sub.3                                      78     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       78     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      78     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      78     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      79     H H       H  --  -- CH.sub.3                                                                            CH.sub.3                                       79     H H       H  --  -- CH.sub.3                                                                            OCH.sub.3                                      79     H 5-OCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      79     H 5-SCH.sub.3                                                                            H  --  -- CH.sub.3                                                                            OCH.sub.3                                      __________________________________________________________________________

                  TABLE 7                                                          ______________________________________                                         General Formula 7                                                                                                           m.p.                              Q        R     R.sub.1  R.sub.3                                                                            W.sub.3                                                                              W.sub.4                                                                             X.sub.3                                                                              (°C.)                      ______________________________________                                         1        H     H        H   O     --   OCH.sub.3                               1        H     5-OCH.sub.3                                                                             H   O     --   OCH.sub.3                               1        H     5-SCH.sub.3                                                                             H   O     --   OCH.sub.3                               1        H     H        H   NCH.sub.3                                                                            --   OCH.sub.3                               1        H     5-OCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               1        H     5-SCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               3        H     H        H   --    --   OCH.sub.3                               3        H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               3        H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               5        H     H        H   NCH.sub.3                                                                            --   OCH.sub.3                               5        H     5-OCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               5        H     5-SCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               7        H     H        H   --    S    OCH.sub.3                               7        H     5-OCH.sub.3                                                                             H   --    S    OCH.sub.3                               7        H     5-SCH.sub.3                                                                             H   --    S    OCH.sub.3                               7        H     H        H   --    SO.sub.2                                                                            OCH.sub.3                               7        H     5-OCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               7        H     5-SCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               8        H     H        H   --    S    OCH.sub.3                               8        H     5-OCH.sub.3                                                                             H   --    S    OCH.sub.3                               8        H     5-SCH.sub.3                                                                             H   --    S    OCH.sub.3                               8        H     H        H   --    SO.sub.2                                                                            OCH.sub.3                               8        H     5-OCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               8        H     5-SCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               16       H     H        H   --    --   OCH.sub.3                               16       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               16       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               19       H     H        H   --    --   OCH.sub.3                               19       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               19       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               20       H     H        H   --    --   OCH.sub.3                               20       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               20       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               21       H     H        H   --    --   OCH.sub.3                               21       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               21       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               22       H     H        H   NCH.sub.3                                                                            --   OCH.sub.3                               22       H     5-OCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               22       H     5-SCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               25       H     H        H   --    S    OCH.sub.3                               25       H     5-OCH.sub.3                                                                             H   --    S    OCH.sub.3                               25       H     5-SCH.sub.3                                                                             H   --    S    OCH.sub.3                               25       H     H        H   --    SO.sub.2                                                                            OCH.sub.3                               25       H     5-OCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               25       H     5-SCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               26       H     H        H   --    S    OCH.sub.3                               26       H     5-OCH.sub.3                                                                             H   --    S    OCH.sub.3                               26       H     5-SCH.sub.3                                                                             H   --    S    OCH.sub.3                               26       H     H        H   --    SO.sub.2                                                                            OCH.sub.3                               26       H     5-OCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               26       H     5-SCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               27       H     H        H   --    S    OCH.sub.3                               27       H     5-OCH.sub.3                                                                             H   --    S    OCH.sub.3                               27       H     5-SCH.sub.3                                                                             H   --    S    OCH.sub.3                               27       H     H        H   --    SO.sub.2                                                                            OCH.sub.3                               27       H     5-OCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               27       H     5-SCH.sub.3                                                                             H   --    SO.sub.2                                                                            OCH.sub.3                               29 (R.sub.6 =CH.sub.3)                                                                  H     H        H   --    --   OCH.sub.3                               29 (R.sub.6 =CH.sub.3)                                                                  H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               29 (R.sub.6 =CH.sub.3)                                                                  H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               55       H     H        H   O     --   OCH.sub.3                               55       H     5-OCH.sub.3                                                                             H   O     --   OCH.sub.3                               55       H     5-SCH.sub.3                                                                             H   O     --   OCH.sub.3                               55       H     H        H   NCH.sub.3                                                                            --   OCH.sub.3                               55       H     5-OCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               55       H     5-SCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               56       H     H        H   --    --   OCH.sub.3                               56       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               56       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               61       H     H        H   NCH.sub.3                                                                            --   OCH.sub.3                               61       H     5-OCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               61       H     5-SCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               62       H     H        H   NCH.sub.3                                                                            --   OCH.sub.3                               62       H     5-OCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               62       H     5-SCH.sub.3                                                                             H   NCH.sub.3                                                                            --   OCH.sub.3                               65       H     H        H   --    --   OCH.sub.3                               65       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               65       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               68       H     H        H   --    --   OCH.sub.3                               68       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               68       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               76       H     H        H   O     --   OCH.sub.3                               76       H     5-OCH.sub.3                                                                             H   O     --   OCH.sub.3                               76       H     5-SCH.sub.3                                                                             H   O     --   OCH.sub.3                               78       H     H        H   --    --   OCH.sub.3                               78       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               78       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               79       H     H        H   --    --   OCH.sub.3                               79       H     5-OCH.sub.3                                                                             H   --    --   OCH.sub.3                               79       H     5-SCH.sub.3                                                                             H   --    --   OCH.sub.3                               ______________________________________                                    

                                      TABLE 8                                      __________________________________________________________________________     General Formula 8                                                              Q        R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                 __________________________________________________________________________     1        H  H       H  O   -- CH.sub.3 CH.sub.3                                1        H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                1        H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                1        H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                1        H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                1        H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                1        H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                1        H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  3-Cl    H  O   -- Cl       OCH.sub.3                               1        CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-CH.sub.3                                                                             H  O   -- OCH.sub. 3                                                                              OCH.sub.3                               1        H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1(R.sub. 5 =CH.sub.3)                                                                   H  H       H  O   -- CH.sub.3 CH.sub.3                                1(R.sub. 5 =CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                1(R.sub. 5 =CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1(R.sub. 5 =CH.sub.3)                                                                   H  H       H  O   -- Cl       OCH.sub.3                               1        H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               1        H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                               1        H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                               1        H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                               1        H  H       H  O   -- CF.sub.3 OCH.sub.3                               1        H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                               1        H  H       H  O   -- Cl       OCH.sub.3                               1        H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                      1        H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                               1        H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                               1        H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                               1        H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                1        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                1        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               1        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                      1        H  H       H  O   -- C.tbd.CH OCH.sub.3                               1        H  H       H  O   -- CHO      OCH.sub.3                               1        H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                         1        H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                             1        H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                             1        H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                1        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                1        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               1        H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                               1        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               1        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               3        H  H       H  --  -- CH.sub.3 CH.sub.3                                3        H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                3        H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               3        H  H       H  --  -- Cl       OCH.sub.3                               3        H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               3        H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               5        H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                5        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                5        H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               5        H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                               5        H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               5        H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               7        H  H       H  --  S  CH.sub.3 CH.sub.3                                7        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                7        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                               7        H  H       H  --  S  Cl       OCH.sub.3                               7        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               7        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               7        H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                7        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                7        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               7        H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                               7        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               7        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               8        H  H       H  --  S  CH.sub.3 CH.sub.3                                8        H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                8        H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                               8        H  H       H  --  S  Cl       OCH.sub.3                               8        H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               8        H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               8        H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                8        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                8        H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               8        H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                               8        H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               8        H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               16       H  H       H  O   -- CH.sub.3 CH.sub.3                                16       H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                16       H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                16       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                16       H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                16       H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                16       H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                16       H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  3-Cl    H  O   -- OCH.sub.3                                                                               Cl                                      16       CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                               16       H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                               16       H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                               16       H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                               16       H  H       H  O   -- CF.sub.3 OCH.sub.3                               16       H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                               16       H  H       H  O   -- Cl       OCH.sub.3                               16       H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                      16       H  H       H  O   -- OCH.sub.2 CH═CH.sub.3                                                               OCH.sub.3                               16       H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                               16       H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                               16       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                16       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                16       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               16       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                      16       H  H       H  O   -- C.tbd.CH OCH.sub.3                               16       H  H       H  O   -- CHO      OCH.sub.3                               16       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                         16       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                             16       H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                             19       H  H       H      -- CH.sub.3 CH.sub.3                                19       H  H       H      -- OCH.sub.3                                                                               CH.sub.3                                19       H  H       H      -- OCH.sub.3                                                                               OCH.sub.3                               19       H  H       H      -- Cl       OCH.sub.3                               19       H  5-OCH.sub.3                                                                            H      -- OCH.sub.3                                                                               OCH.sub.3                               19       H  5-SCH.sub.3                                                                            H      -- OCH.sub.3                                                                               OCH.sub.3                               20       H  H       H      -- CH.sub.3 CH.sub.3                                20       H  H       H      -- OCH.sub.3                                                                               CH.sub.3                                20       H  H       H      -- OCH.sub.3                                                                               OCH.sub.3                               20       H  H       H      -- Cl       OCH.sub.3                               20       H  5-OCH.sub.3                                                                            H      -- OCH.sub.3                                                                               OCH.sub.3                               20       H  5-SCH.sub.3                                                                            H      -- OCH.sub.3                                                                               OCH.sub.3                               21       H  H       H      -- CH.sub.3 CH.sub.3                                21       H  H       H      -- OCH.sub.3                                                                               CH.sub.3                                21       H  H       H      -- OCH.sub.3                                                                               OCH.sub.3                               21       H  H       H  --  -- Cl       OCH.sub.3                               21       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               21       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               22       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                22       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                22       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               22       H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                               22       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               22       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               25       H  H       H  --  S  CH.sub.3 CH.sub.3                                25       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                25       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                               25       H  H       H  --  S  Cl       OCH.sub.3                               25       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               25       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               25       H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                25       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                25       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               25       H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                               25       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               25       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               26       H  H       H  --  S  CH.sub.3 CH.sub.3                                26       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                26       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                               26       H  H       H  --  S  Cl       OCH.sub.3                               26       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               26       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               26       H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                26       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                26       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               26       H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                               26       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               26       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               27       H  H       H  --  S  CH.sub.3 CH.sub.3                                27       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                27       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                               27       H  H       H  --  S  Cl       OCH.sub.3                               27       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               27       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                               27       H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                27       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                27       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               27       H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                               27       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               27       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                               29(R.sub. 6 =CH.sub.3)                                                                  H  H       H  --  -- CH.sub.3 CH.sub.3                                29(R.sub. 6 =CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                29(R.sub. 6 =CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               29(R.sub. 6 =CH.sub.3)                                                                  H  H       H  --  -- Cl       OCH.sub.3                               29(R.sub. 6 =CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               29(R.sub. 6 =CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               55       H  H       H  O   -- CH.sub.3 CH.sub.3                                55       H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                55       H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               55       H  H       H  O   -- Cl       OCH.sub.3                               55       H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               55       H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               55       H  H       H  NCH.sub.3                                                                          -- CH.sub. 3                                                                               CH.sub.3                                55       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                55       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               55       H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                               55       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               55       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               56       H  H       H  --  -- CH.sub.3 CH.sub.3                                56       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                56       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               56       H  H       H  --  -- Cl       OCH.sub.3                               56       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               56       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               61       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                61       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                61       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               61       H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                               61       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               61       H  5-SCH.sub. 3                                                                           H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               62       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                62       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                62       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               62       H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                               62       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               62       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                               65       H  H       H  --  -- CH.sub.3 CH.sub.3                                65       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                65       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               65       H  H       H  --  -- Cl       OCH.sub.3                               65       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               65       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               68       H  H       H  --  -- CH.sub.3 CH.sub.3                                68       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                68       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               68       H  H       H  --  -- Cl       OCH.sub.3                               68       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               68       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               76       H  H       H  O   -- CH.sub.3 CH.sub.3                                76       H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                76       H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                               76       H  H       H  O   -- Cl       OCH.sub.3                               76       H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               76       H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                               78       H  H       H  --  -- CH.sub.3 CH.sub.3                                78       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                78       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               78       H  H       H  --  -- Cl       OCH.sub.3                               78       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               78       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               79       H  H       H  --  -- CH.sub.3 CH.sub.3                                79       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                79       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                               79       H  H       H  --  -- Cl       OCH.sub.3                               79       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               79       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               80(R.sub. 3,R.sub.4 =CH.sub.3)                                                          H  H       H  --  -- CH.sub.3 CH.sub.3                                                                              95-103                           80(R.sub. 3,R.sub.4 =CH.sub.3)                                                          H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                                                              99-103                           80(R.sub. 3,R.sub.4 =CH.sub.3)                                                          H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            104-112                           80(R.sub. 3,R.sub.4 =CH.sub.3)                                                          H  H       H  --  -- Cl       OCH.sub.3                                                                            103-112                           80(R.sub. 3,R.sub.4 =CH.sub.3)                                                          H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               80(R.sub. 3,R.sub.4 =CH.sub.3)                                                          H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                               __________________________________________________________________________

                                      TABLE 9                                      __________________________________________________________________________     General Formula 9                                                              Q       R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                  __________________________________________________________________________     1       H  H       H  O   -- CH.sub.3 CH.sub.3                                 1       H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                 1       H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                 1       H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1(R.sub.5 =CH.sub.3)                                                                   H  H       H  O   -- CH.sub.3 CH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                   H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                1       H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                1       H  H       H  O   -- CF.sub.3 OCH.sub.3                                1       H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       1       H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                1       H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                1       H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                1       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 1       H  H       H  O   -- C.tbd.CH OCH.sub.3                                1       H  H       H  O   -- CHO      OCH.sub.3                                1       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          1       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              1       H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  NCH.sub.3                                                                          -- OCH.sub. 3                                                                              CH.sub.3                                 1       CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       H  NCH -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               1       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                3       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                3       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 3       CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 3       H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               3       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                3       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 5       CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               5       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                5       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 7       CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 7       H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               7       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 7       CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 7       H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               7       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                7       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 8       CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 8       H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               8       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 8       CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 8       H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               8       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- CH.sub.3 CH.sub.3                                 16      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                 16      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                 16      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                16      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                16      H  H       H  O   -- CF.sub.3 OCH.sub.3                                16      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       16      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                16      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                16      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                16      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- C.tbd.CH OCH.sub.3                                16      H  H       H  O   -- CHO      OCH.sub.3                                16      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          16      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              16      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              19      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                19      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 19      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 19      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               19      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                19      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 20      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 20      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               20      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 21      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 21      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               21      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 22      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               22      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                22      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 25      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 25      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               25      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 25      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 25      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               25      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                25      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 26      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 26      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               26      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 26      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 26      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               26      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 27      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 27      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               27      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 27      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 27      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               27      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                  H  H       H  --  -- OCH.sub. 3                                                                              CH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                  CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                  H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               29(R.sub.6 =CH.sub.3)                                                                  H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                  H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 55      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 55      H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               55      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 55      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               55      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                55      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                56      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                56      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 56      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 56      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               56      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                56      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 61      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               61      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                61      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 62      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               62      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                65      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                65      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 65      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 65      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               65      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                65      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 68      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 68      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               68      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                76      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                76      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 76      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 76      H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               76      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                76      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                78      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                78      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 78      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 78      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               78      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                78      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 79      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 79      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               79      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                                                            110-116                            80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                                                             104-110                            80(R.sub.4,R.sub.5 =CH.sub.3)                                                          CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                80(R.sub.4,R.sub.5 =CH.sub.3)                                                          H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                __________________________________________________________________________

                                      TABLE 10                                     __________________________________________________________________________     General Structure 10                                                           Q      R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                            X        Y     m.p. (°C.)                  __________________________________________________________________________     1      H  H       H  O   --  CH.sub.3 CH.sub.3                                 1      H  H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 1      H  H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      CH.sub.3                                                                          H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      CH.sub.3                                                                          H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 1      H  H       CH.sub.3                                                                          O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  H       CH.sub.3                                                                          O   --  OCH.sub.3                                                                               CH.sub.3                                 1      H  H       CH.sub.3                                                                          O   --  CH.sub.3 CH.sub.3                                 1      H  3-Cl    H  O   --  CH.sub.3 CH.sub.3                                 1      H  3-Cl    H  O   --  OCH.sub.3                                                                               CH.sub.3                                 1      H  3-Cl    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  3-Cl    H  O   --  Cl       OCH.sub.3                                1      CH.sub.3                                                                          3-Cl    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-CH.sub.3                                                                             H  O   --  OCH.sub. 3                                                                              OCH.sub.3                                1      H  5-OCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-OCF.sub.2 H                                                                          H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-SCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-NHCH.sub.3                                                                           H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-N(CH.sub.3).sub.2                                                                    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-Cl    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-CF.sub.3                                                                             H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  6-CO.sub.2 CH.sub.3                                                                    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   --  CH.sub.3 CH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   --  Cl       OCH.sub.3                                1      H  6-SO.sub.2 CH.sub.3                                                                    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                1      H  H       H  O   --  OCF.sub.2 H                                                                             OCH.sub.3                                1      H  H       H  O   --  CH.sub.2 F                                                                              OCH.sub.3                                1      H  H       H  O   --  CH.sub.2 Cl                                                                             OCH.sub.3                                1      H  H       H  O   --  CF.sub.3 OCH.sub.3                                1      H  H       H  O   --  SCH.sub.3                                                                               OCH.sub.3                                1      H  H       H  O   --  Cl       OCH.sub.3                                1      H  H       H  O   --  NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       1      H  H       H  O   --  OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                1      H  H       H  O   --  OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                1      H  H       H  O   --  cyclopropyl                                                                             OCH.sub.3                                1      H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                1      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               Cl                                       1      H  H       H  O   --  C.tbd.CH OCH.sub.3                                1      H  H       H  O   --  CHO      OCH.sub.3                                1      H  H       H  O   --  2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          1      H  H       H  O   --  2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              1      H  H       H  O   --  1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              1      H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                1      H  H       H  NCH.sub.3                                                                          --  Cl       OCH.sub.3                                1      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                1      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                3      H  H       H  --  --  CH.sub.3 CH.sub.3                                 3      H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 3      H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                3      H  H       H  --  --  Cl       OCH.sub.3                                3      H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                3      H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                5      H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                5      H  H       H  NCH.sub.3                                                                          --  Cl       OCH.sub.3                                5      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                5      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                7      H  H       H  --  S   CH.sub.3 CH.sub.3                                 7      H  H       H  --  S   OCH.sub.3                                                                               CH.sub.3                                 7      H  H       H  --  S   OCH.sub.3                                                                               OCH.sub.3                                7      H  H       H  --  S   Cl       OCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                7      H  5-SCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                7      H  H       H  --  SO.sub.2                                                                           CH.sub.3 CH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               CH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                7      H  H       H  --  SO.sub.2                                                                           Cl       OCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                7      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                8      H  H       H  --  S   CH.sub.3 CH.sub.3                                 8      H  H       H  --  S   OCH.sub.3                                                                               CH.sub.3                                 8      H  H       H  --  S   OCH.sub.3                                                                               OCH.sub.3                                8      H  H       H  --  S   Cl       OCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                8      H  5-SCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                8      H  H       H  --  SO.sub.2                                                                           CH.sub.3 CH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               CH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                8      H  H       H  --  SO.sub.2                                                                           Cl       OCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                8      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                16     H  H       H  O   --  CH.sub.3 CH.sub.3                                 16     H  H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 16     H  H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     CH.sub.3                                                                          H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     CH.sub.3                                                                          H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 16     H  H       CH.sub.3                                                                          O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  H       CH.sub.3                                                                          O   --  OCH.sub.3                                                                               CH.sub.3                                 16     H  H       CH.sub.3                                                                          O   --  CH.sub.3 CH.sub.3                                 16     H  3-Cl    H  O   --  CH.sub.3 CH.sub.3                                 16     H  3-Cl    H  O   --  OCH.sub.3                                                                               CH.sub.3                                 16     H  3-Cl    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  3-Cl    H  O   --  OCH.sub.3                                                                               Cl                                       16     CH.sub.3                                                                          3-Cl    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-CH.sub.3                                                                             H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-OCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-OCH.sub.2 CH.sub.3                                                                   H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-OCF.sub.2 H                                                                          H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-SCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-NHCH.sub.3                                                                           H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-N(CH.sub.3).sub.2                                                                    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-Cl    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  5-CF.sub.3                                                                             H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  6-CO.sub.2 CH.sub.3                                                                    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  6-SO.sub.2 CH.sub.3                                                                    H  O   --  OCH.sub.3                                                                               OCH.sub.3                                16     H  H       H  O   --  OCF.sub.2 H                                                                             OCH.sub.3                                16     H  H       H  O   --  CH.sub.2 F                                                                              OCH.sub.3                                16     H  H       H  O   --  CH.sub.2 Cl                                                                             OCH.sub.3                                16     H  H       H  O   --  CF.sub.3 OCH.sub.3                                16     H  H       H  O   --  SCH.sub.3                                                                               OCH.sub.3                                16     H  H       H  O   --  Cl       OCH.sub.3                                16     H  H       H  O   --  NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       16     H  H       H  O   --  OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                16     H  H       H  O   --  OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                16     H  H       H  O   --  cyclopropyl                                                                             OCH.sub.3                                16     H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                16     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               Cl                                       16     H  H       H  O   --  C.tbd.CH OCH.sub.3                                16     H  H       H  O   --  CHO      OCH.sub.3                                16     H  H       H  O   --  2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          16     H  H       H  O   --  2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              16     H  H       H  O   --  1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              19     H  H       H  --  --  CH.sub.3 CH.sub.3                                 19     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 19     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                19     H  H       H  --  --  Cl       OCH.sub.3                                19     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                19     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                20     H  H       H  --  --  CH.sub.3 CH.sub.3                                 20     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 20     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                20     H  H       H  --  --  Cl       OCH.sub.3                                20     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                20     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                21     H  H       H  --  --  CH.sub.3 CH.sub.3                                 21     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 21     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                21     H  H       H  --  --  Cl       OCH.sub.3                                21     H  5-OCH.sub.3                                                                            H  --  OCH.sub.3                                                                          --       OCH.sub.3                                21     H  5-SCH.sub.3                                                                            H  --  OCH.sub.3                                                                          --       OCH.sub.3                                22     H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                22     H  H       H  NCH.sub.3                                                                          --  Cl       OCH.sub.3                                22     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                22     H  5-SCH.sub.3                                                                            H  NCH.sub. 3                                                                         --  OCH.sub.3                                                                               OCH.sub.3                                25     H  H       H  --  S   CH.sub.3 CH.sub.3                                 25     H  H       H  --  S   OCH.sub.3                                                                               CH.sub.3                                 25     H  H       H  --  S   OCH.sub.3                                                                               OCH.sub.3                                25     H  H       H  --  S   Cl       OCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                25     H  5-SCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                25     H  H       H  --  SO.sub.2                                                                           CH.sub.3 CH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               CH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                25     H  H       H  --  SO.sub.2                                                                           Cl       OCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                25     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                26     H  H       H  --  S   CH.sub.3 CH.sub.3                                 26     H  H       H  --  S   OCH.sub.3                                                                               CH.sub.3                                 26     H  H       H  --  S   OCH.sub.3                                                                               OCH.sub.3                                26     H  H       H  --  S   Cl       OCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                26     H  5-SCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                26     H  H       H  --  SO.sub.2                                                                           CH.sub.3 CH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               CH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                26     H  H       H  --  SO.sub.2                                                                           Cl       OCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                26     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                27     H  H       H  --  S   CH.sub.3 CH.sub.3                                 27     H  H       H  --  S   OCH.sub.3                                                                               CH.sub.3                                 27     H  H       H  --  S   OCH.sub.3                                                                               OCH.sub.3                                27     H  H       H  --  S   Cl       OCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                27     H  5-SCH.sub.3                                                                            H  --  S   OCH.sub.3                                                                               OCH.sub.3                                27     H  H       H  --  SO.sub.2                                                                           CH.sub.3 CH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               CH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                27     H  H       H  --  SO.sub.2                                                                           Cl       OCH.sub. 3                               27     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                27     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                           OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  --  CH.sub.3 CH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  --  Cl       OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                55     H  H       H  O   --  CH.sub.3 CH.sub.3                                 55     H  H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 55     H  H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                55     H  H       H  O   --  Cl       OCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                55     H  5-SCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                55     H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                55     H  H       H  NCH.sub.3                                                                          --  Cl       OCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                55     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                56     H  H       H  --  --  CH.sub.3 CH.sub.3                                 56     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 56     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                56     H  H       H  --  --  Cl       OCH.sub.3                                56     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                56     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                61     H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                61     H  H       H  NCH.sub.3                                                                          --  Cl       OCH.sub.3                                61     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub. 3                                                                              OCH.sub.3                                61     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                62     H  H       H  NCH.sub.3                                                                          --  CH.sub.3 CH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               CH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                62     H  H       H  NCH.sub.3                                                                          --  Cl       OCH.sub.3                                62     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                62     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          --  OCH.sub.3                                                                               OCH.sub.3                                65     H  H       H  --  --  CH.sub.3 CH.sub.3                                 65     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 65     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                65     H  H       H  --  --  Cl       OCH.sub.3                                65     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                65     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                68     H  H       H  --  --  CH.sub.3 CH.sub.3                                 68     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 68     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                68     H  H       H  --  --  Cl       OCH.sub.3                                68     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                68     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                76     H  H       H  O   --  CH.sub.3 CH.sub.3                                 76     H  H       H  O   --  OCH.sub.3                                                                               CH.sub.3                                 76     H  H       H  O   --  OCH.sub.3                                                                               OCH.sub.3                                76     H  H       H  O   --  Cl       OCH.sub.3                                76     H  5-OCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                76     H  5-SCH.sub.3                                                                            H  O   --  OCH.sub.3                                                                               OCH.sub.3                                78     H  H       H  --  --  CH.sub.3 CH.sub.3                                 78     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 78     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                78     H  H       H  --  --  Cl       OCH.sub.3                                78     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                78     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                79     H  H       H  --  --  CH.sub.3 CH.sub.3                                 79     H  H       H  --  --  OCH.sub.3                                                                               CH.sub.3                                 79     H  H       H  --  --  OCH.sub.3                                                                               OCH.sub.3                                79     H  H       H  --  --  Cl       OCH.sub.3                                79     H  5-OCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                79     H  5-SCH.sub.3                                                                            H  --  --  OCH.sub.3                                                                               OCH.sub.3                                __________________________________________________________________________

                                      TABLE 11                                     __________________________________________________________________________     General Formula 11                                                             Q      R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p.(°C.)                    __________________________________________________________________________     1      H  H       H  O   -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 1      H  H       H  O   -- CH.sub. 2 Cl                                                                            OCH.sub.3                                 1      H  H       H  O   -- CF.sub.3 OCH.sub.3                                 1      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        1      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 1      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 1      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- C.tbd.CH OCH.sub.3                                 1      H  H       H  O   -- CHO      OCH.sub.3                                 1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               1      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                1      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                3      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                5      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub. -7 H H H -- S OCH.sub.3 OCH.                                          sub.3                                     7      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                8      H  5-OCH.sub. 3                                                                           H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub.3 CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub. 2 F                                                                             OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 16     H  H       H  O   -- CF.sub.3 OCH.sub.3                                 16     H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        16     H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 16     H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 16     H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- C.tbd.CH OCH.sub.3                                 16     H  H       H  O   -- CHO      OCH.sub.3                                 16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               16     H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               19     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                19     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                20     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub. 3                                 21     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                21     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                22     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub. 3                                25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub. 3                                26     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub. 3)                                                                CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                56     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- CH.sub.2 CH.sub.3                                                                       NHCH.sub.3                                61     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                62     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                65     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                68     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                76     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                78     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub. 3                               79     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 __________________________________________________________________________

                                      TABLE 12                                     __________________________________________________________________________     General Formula 12                                                             Q      R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p.(°C.)                    __________________________________________________________________________     1      H  H       H  O   -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  3-Cl    H  O   -- Cl       OCH.sub.3                                 1      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- Cl       OCH.sub.3                                 1      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 1      H  H       H  O   -- CF.sub.3 OCH.sub.3                                 1      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- Cl       OCH.sub.3                                 1      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        1      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 1      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 1      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                        1      H  H       H  O   -- C.tbd.CH OCH.sub.3                                 1      H  H       H  O   -- CHO      OCH.sub.3                                 1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               1      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               1      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- CH.sub.3 CH.sub.3                                  3      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- Cl       OCH.sub.3                                 3      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 5      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  CH.sub.3 CH.sub.3                                  7      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  Cl       OCH.sub.3                                 7      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 7      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  CH.sub.3 CH.sub.3                                  8      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  Cl       OCH.sub.3                                 8      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 8      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  --  O  CH.sub.3 CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub. 3                                16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  3-Cl    H  O   -- OCH.sub.3                                                                               Cl                                        16     CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-Cl    H  O   -- OCH.sub. 3                                                                              OCH.sub.3                                 16     H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 16     H  H       H  O   -- CF.sub.3 OCH.sub.3                                 16     H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- Cl       OCH.sub.3                                 16     H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        16     H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 16     H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 16     H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub. 3                                 16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                        16     H  H       H  O   -- C.tbd.CH OCH.sub.3                                 16     H  H       H  O   -- CHO      OCH.sub.3                                 16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               16     H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               19     H  H       H  --  -- CH.sub.3 CH.sub.3                                  19     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  H       H  --  -- Cl       OCH.sub.3                                 19     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- CH.sub.3 CH.sub.3                                  20     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- Cl       OCH.sub.3                                 20     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- CH.sub.3 CH.sub.3                                  21     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- Cl       OCH.sub.3                                 21     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 22     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  CH.sub.3 CH.sub.3                                  25     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  Cl       OCH.sub.3                                 25     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 25     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  CH.sub.3 CH.sub.3                                  26     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  Cl       OCH.sub.3                                 26     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub. 3                                                                           H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 26     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  CH.sub.3 CH.sub.3                                  27     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  Cl       OCH.sub.3                                 27     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 27     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- CH.sub.3 CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- Cl       OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- CH.sub.3 CH.sub.3                                  55     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- Cl       OCH.sub.3                                 55     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 55     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- CH.sub.3 CH.sub.3                                  56     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- Cl       OCH.sub.3                                 56     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 61     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 62     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- CH.sub.3 CH.sub.3                                  65     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- Cl       OCH.sub.3                                 65     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- CH.sub.3 CH.sub.3                                  68     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- Cl       OCH.sub.3                                 68     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  5-SCH3  H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- CH.sub.3 CH.sub.3                                  76     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- Cl       OCH.sub.3                                 76     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- CH.sub.3 CH.sub.3                                  78     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- Cl       OCH.sub.3                                 78     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- CH.sub.3 CH.sub.3                                  79     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- Cl       OCH.sub.3                                 79     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 __________________________________________________________________________

                                      TABLE 13                                     __________________________________________________________________________     General Structure 13                                                           Q      R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                   __________________________________________________________________________     1      H  H       H  O   -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 1      H  H       H  O   -- CF.sub.3 OCH.sub.3                                 1      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        1      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 1      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 1      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- C.tbd.CH OCH.sub.3                                 1      H  H       H  O   -- CHO      OCH.sub.3                                 1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               1      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                1      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                3      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                5      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub.3 CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 16     H  H       H  O   -- CF.sub.3 OCH.sub.3                                 16     H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        16     H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 16     H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 16     H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- C.tbd.CH OCH.sub.3                                 16     H  H       H  O   -- CHO      OCH.sub.3                                 16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               16     H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               19     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                19     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                20     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                21     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                22     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                56     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- OCH.sub. 2 CH.sub.3                                                                     NHCH.sub.3                                61     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                62     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                65     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                68     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                76     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                78     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                79     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 __________________________________________________________________________

                                      TABLE 14                                     __________________________________________________________________________     General Structure 14                                                           Q      R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                   __________________________________________________________________________     1      H  H       H  O   -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  3-Cl    H  O   -- Cl       OCH.sub.3                                 1      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub. 3                                1      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- Cl       OCH.sub.3                                 1      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 1      H  H       H  O   -- CF.sub.3 OCH.sub.3                                 1      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- Cl       OCH.sub.3                                 1      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        1      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 1      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 1      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- OCH.sub. 3                                                                              Cl                                        1      H  H       H  O   -- C.tbd.CH OCH.sub.3                                 1      H  H       H  O   -- CHO      OCH.sub.3                                 1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               1      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                                      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- CH.sub.3 CH.sub.3                                  3      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- Cl       OCH.sub.3                                 3      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  5-SCH.sub.3                                                                            H  -   -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 5      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  CH.sub.3 CH.sub.3                                  7      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  Cl       OCH.sub.3                                 7      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 7      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  CH.sub.3 CH.sub.3                                  8      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  Cl       OCH.sub.3                                 8      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 8      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub.3 CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  3-Cl    H  O   -- OCH.sub.3                                                                               Cl                                        16     CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub. 3                                                                              OCH.sub.3                                 16     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 16     H  H       H  O   -- CF.sub.3 OCH.sub.3                                 16     H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- Cl       OCH.sub.3                                 16     H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        16     H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 16     H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 16     H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                        16     H  H       H  O   -- C.tbd.CH OCH.sub.3                                 16     H  H       H  O   -- CHO      OCH.sub.3                                 16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               16     H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               19     H  H       H  --  -- CH.sub.3 CH.sub.3                                  19     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  H       H  --  -- Cl       OCH.sub.3                                 19     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- CH.sub.3 CH.sub.3                                  20     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- Cl       OCH.sub.3                                 20     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- CH.sub.3 CH.sub.3                                  21     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- Cl       OCH.sub.3                                 21     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 22     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  CH.sub.3 CH.sub.3                                  25     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  Cl       OCH.sub.3                                 25     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub. 3                                25     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  CH.sub.3 CH.sub.3                                  26     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  Cl       OCH.sub.3                                 26     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 26     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  CH.sub.3 CH.sub.3                                  27     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  Cl       OCH.sub.3                                 27     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                 27     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- CH.sub.3 CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- Cl       OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- CH.sub.3 CH.sub.3                                  55     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- Cl       OCH.sub.3                                 55     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 55     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- CH.sub.3 CH.sub.3                                  56     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- Cl       OCH.sub.3                                 56     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 61     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                 62     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- CH.sub.3 CH.sub.3                                  65     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- Cl       OCH.sub.3                                 65     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- CH.sub.3 CH.sub.3                                  68     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- Cl       OCH.sub.3                                 68     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- CH.sub.3 CH.sub.3                                  76     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- Cl       OCH.sub.3                                 76     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- CH.sub.3 CH.sub.3                                  78     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- Cl       OCH.sub.3                                 78     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- CH.sub.3 CH.sub.3                                  79     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- Cl       OCH.sub.3                                 79     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 __________________________________________________________________________

                                      TABLE 15                                     __________________________________________________________________________     General Structure 15                                                           Q       R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°                     __________________________________________________________________________                                                 C.)                                1       H  H       H  O   -- CH.sub.3 CH.sub.3                                 1       H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                 1       H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                 1       H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                 1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                1       H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                1       H  H       H  O   -- CF.sub.3 OCH.sub.3                                1       H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       1       H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                1       H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                1       H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                1       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 1       H  H       H  O   -- C.tbd.CH OCH.sub.3                                1       H  H       H  O   -- CHO      OCH.sub.3                                1       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          1       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              1       H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 1       CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               1       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                3       H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                3       H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 3       CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 3       H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               3       H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                3       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 5       CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               5       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                5       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 7       CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 7       H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               7       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 7       CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 7       H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               7       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                7       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 8       CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 8       H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               8       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 8       CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 8       H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               8       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- CH.sub.3 CH.sub.3                                 16      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                 16      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                 16      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                16      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                16      H  H       H  O   -- CF.sub.3 OCH.sub.3                                16      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       16      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                16      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                16      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                16      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- C.tbd.CH OCH.sub.3                                16      H  H       H  O   -- CHO      OCH.sub.3                                16      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          16      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              16      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              19      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                19      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 19      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 19      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               19      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                19      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 20      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 20      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               20      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  H       H  --  -- OCH.sub.3                                                                               CH.sub. 3                                21      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 21      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               21      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 22      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               22      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                22      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 25      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 25      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               25      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 25      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 25      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               25      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                25      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 26      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 26      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               26      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 26      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 26      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub. 3                              26      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 27      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 27      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               27      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 27      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 27      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               27      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 = CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6  = CH.sub.3)                                                                H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 29(R.sub.6 = CH.sub.3)                                                                 CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 29(R.sub.6 = CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               29(R.sub.6 = CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 = CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 55      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 55      H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               55      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 55      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               55      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                55      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                56      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                56      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 56      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 56      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               56      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                56      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 61      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               61      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                61      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 62      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               62      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                65      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                65      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 65      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 65      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               65      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                65      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 68      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 68      H  H       H  --  -- OCH.sub.2 CH.sub. 3                                                                     NHCH.sub.3                               68      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                76      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                76      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 76      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 76      H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               76      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                76      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                78      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                78      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 78      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 78      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               78      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                78      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 79      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 79      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                               79      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                __________________________________________________________________________

                                      TABLE 16                                     __________________________________________________________________________     General Structure 16                                                           Q       R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                  __________________________________________________________________________     1       H  H       H  O   -- CH.sub.3 CH.sub.3                                 1       H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                 1       H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                 1       H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1       H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  3-Cl    H  O   -- Cl       OCH.sub.3                                1       CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub. 3                               1       H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                 1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1(R.sub.5 = CH.sub.3)                                                                  H  H       H  O   -- Cl       OCH.sub.3                                1       H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                                1       H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                1       H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                1       H  H       H  O   -- CF.sub.3 OCH.sub.3                                1       H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  O   -- Cl       OCH.sub.3                                1       H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       1       H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                1       H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                1       H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                1       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                1       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                       1       H  H       H  O   -- C.tbd.CH OCH.sub.3                                1       H  H       H  O   -- CHO      OCH.sub.3                                1       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          1       H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              1       H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              1       H  H       H  NCH.sub.3                                                                          -- --       CH.sub.3                                                                             CH.sub.3                           1       H  H       H  NCH.sub.3                                                                          -- --       OCH.sub.3                                                                            CH.sub.3                           1       H  H       H  NCH.sub.3                                                                          -- --       OCH.sub.3                                                                            OCH.sub.3                          1       H  H       H  NCH.sub.3                                                                          -- --       Cl    OCH.sub.3                          1       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- --       OCH.sub.3                                                                            OCH.sub.3                          1       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- --       OCH.sub.3                                                                            OCH.sub.3                          3       H  H       H  --  -- --       CH.sub.3                                                                             CH.sub.3                           3       H  H       H  --  -- --       OCH.sub.3                                                                            CH.sub.3                           3       H  H       H  --  -- --       OCH.sub.3                                                                            OCH.sub.3                          3       H  H       H  --  -- --       Cl    OCH.sub.3                          3       H  5-OCH.sub.3                                                                            H  --  -- --       OCH.sub.3                                                                            OCH.sub.3                          3       H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                5       H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 5       H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                5       H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                5       H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                5       H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  S  CH.sub.3 CH.sub.3                                 7       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 7       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  S  Cl       OCH.sub.3                                7       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                 7       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 7       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                7       H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                7       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                7       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  S  CH.sub.3 CH.sub.3                                 8       H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 8       H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  S  Cl       OCH.sub.3                                8       H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                 8       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 8       H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                8       H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                8       H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- CH.sub.3 CH.sub.3                                 16      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                 16      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                 16      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                 16      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  3-Cl    H  O   -- OCH.sub.3                                                                               Cl                                       16      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- OCF.sub.2 H                                                                             OCH.sub.3                                16      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                16      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                16      H  H       H  O   -- CF.sub.3 OCH.sub.3                                16      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  O   -- Cl       OCH.sub.3                                16      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                       16      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                16      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                16      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                16      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                16      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               Cl                                       16      H  H       H  O   -- C.tbd.CH OCH.sub.3                                16      H  H       H  O   -- CHO      OCH.sub.3                                16      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                          16      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                              16      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                              19      H  H       H  --  -- CH.sub.3 CH.sub.3                                 19      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 19      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                19      H  H       H  --  -- Cl       OCH.sub.3                                19      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                19      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  H       H  --  -- CH.sub.3 CH.sub.3                                 20      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 20      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  H       H  --  -- Cl       OCH.sub.3                                20      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                20      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  H       H  --  -- CH.sub.3 CH.sub.3                                 21      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 21      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  H       H  --  -- Cl       OCH.sub.3                                21      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                21      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                22      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 22      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                22      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                22      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                22      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  S  CH.sub.3 CH.sub.3                                 25      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 25      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  S  Cl       OCH.sub.3                                25      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                 25      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 25      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                25      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                25      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                25      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  S  CH.sub.3 CH.sub.3                                 26      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 26      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  S  Cl       OCH.sub.3                                26      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                 26      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 26      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                26      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                26      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  S  CH.sub.3 CH.sub.3                                 27      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                 27      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  S  Cl       OCH.sub.3                                27      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  SO.sub.2                                                                          CH.sub.3 CH.sub.3                                 27      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                 27      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  H       H  --  SO.sub.2                                                                          Cl       OCH.sub.3                                27      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                27      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 = CH.sub.3)                                                                 H  H       H  --  -- CH.sub.3 CH.sub.3                                 29(R.sub.6 = CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 29(R.sub.6 = CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 = CH.sub.3)                                                                 H  H       H  --  -- Cl       OCH.sub.3                                29(R.sub.6 = CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                29(R.sub.6 = CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  O   -- CH.sub.3 CH.sub.3                                 55      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 55      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  O   -- Cl       OCH.sub.3                                55      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 55      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                55      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                55      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                55      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                56      H  H       H  --  -- CH.sub.3 CH.sub.3                                 56      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 56      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                56      H  H       H  --  -- Cl       OCH.sub.3                                56      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                56      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                61      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 61      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                61      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                61      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                61      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                 62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                 62      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  H       H  NCH.sub.3                                                                          -- Cl       OCH.sub.3                                62      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                62      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                65      H  H       H  --  -- CH.sub.3 CH.sub.3                                 65      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 65      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                65      H  H       H  --  -- Cl       OCH.sub.3                                65      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                65      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  H       H  --  -- CH.sub.3 CH.sub.3                                 68      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 68      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  H       H  --  -- Cl       OCH.sub.3                                68      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                68      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                76      H  H       H  O   -- CH.sub.3 CH.sub.3                                 76      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                 76      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                76      H  H       H  O   -- Cl       OCH.sub.3                                76      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                76      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                78      H  H       H  --  -- CH.sub.3 CH.sub.3                                 78      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 78      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                78      H  H       H  --  -- Cl       OCH.sub.3                                78      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                78      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  H       H  --  -- CH.sub.3 CH.sub.3                                 79      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                 79      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  H       H  --  -- Cl       OCH.sub.3                                79      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                79      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                __________________________________________________________________________

                                      TABLE 17                                     __________________________________________________________________________     General Structure 17                                                           Q      R  R.sub.1 R.sub.3                                                                           W.sub.3                                                                            W.sub.4                                                                           X        Y     m.p. (°C.)                   __________________________________________________________________________     1      H  H       H  O   -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1      H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- CH.sub.3 CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  1(R.sub.5 =CH.sub.3)                                                                  H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 1      H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 1      H  H       H  O   -- CF.sub.3 OCH.sub.3                                 1      H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        1      H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 1      H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 1      H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  1      H  H       H  O   -- C.tbd.CH OCH.sub.3                                 1      H  H       H  O   -- CHO      OCH.sub.3                                 1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           1      H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               1      H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  1      H  H       H  NCH -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                1      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 1      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  3      H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                3      H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 3      H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  5      H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                5      H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 5      H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  7      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                7      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 7      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  8      H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                8      H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 8      H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub.3 CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       CH.sub.3                                                                          O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       CH.sub.3                                                                          O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- CH.sub.3 CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               CH.sub.3                                  16     H  3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     CH.sub.3                                                                          3-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CH.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCH.sub.2 CH.sub.3                                                                   H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-OCF.sub.2 H                                                                          H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-NHCH.sub.3                                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-N(CH.sub.3).sub.2                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-Cl    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  5-CF.sub.3                                                                             H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 N(CH.sub.3).sub.2                                                           H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-CO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  6-SO.sub.2 CH.sub.3                                                                    H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 F                                                                              OCH.sub.3                                 16     H  H       H  O   -- CH.sub.2 Cl                                                                             OCH.sub.3                                 16     H  H       H  O   -- CF.sub.3 OCH.sub.3                                 16     H  H       H  O   -- SCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                        16     H  H       H  O   -- OCH.sub.2 CH═CH.sub.2                                                               OCH.sub.3                                 16     H  H       H  O   -- OCH.sub.2 C.tbd.CH                                                                      OCH.sub.3                                 16     H  H       H  O   -- cyclopropyl                                                                             OCH.sub.3                                 16     H  H       H  NCH.sub.3                                                                          -- CH.sub.3 CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  16     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 16     H  H       H  O   -- C.tbd.CH OCH.sub.3                                 16     H  H       H  O   -- CHO      OCH.sub.3                                 16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-oxathio-                                                                   lan-2-yl                                           16     H  H       H  O   -- 2-methyl-                                                                               OCH.sub.3                                                             1,3-dithian-                                                                   2-yl                                               16     H  H       H  O   -- 1,3-dioxan-                                                                             OCH.sub.3                                                             2-yl                                               19     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  19     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                19     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 19     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  20     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                20     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 20     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  21     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                21     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 21     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  22     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                22     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 22     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub. 3                                                                              OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  25     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                25     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 25     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  26     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                26     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 26     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     CH.sub.3                                                                          H       H  --  S  OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  S  OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  S  OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     CH.sub.3                                                                          H       H  --  SO.sub.2                                                                          OCH.sub.3                                                                               CH.sub.3                                  27     H  H       H  --  SO.sub.2                                                                          OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                27     H  5-OCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 27     H  5-SCH.sub.3                                                                            H  --  SO.sub.2                                                                          OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  29(R.sub.6 =CH.sub.3)                                                                 H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                29(R.sub.6 =CH.sub.3)                                                                 H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 29(R.sub.6 =CH.sub.3)                                                                 H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  55     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                55     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 55     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  56     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                56     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 56     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  61     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                61     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 61     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     CH.sub.3                                                                          H       H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               CH.sub.3                                  62     H  H       H  NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                62     H  5-OCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 62     H  5-SCH.sub.3                                                                            H  NCH.sub.3                                                                          -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  65     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                65     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 65     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  68     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                68     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 68     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     CH.sub.3                                                                          H       H  O   -- OCH.sub.3                                                                               CH.sub.3                                  76     H  H       H  O   -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                76     H  5-OCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 76     H  5-SCH.sub.3                                                                            H  O   -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  78     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                78     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 78     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     CH.sub.3                                                                          H       H  --  -- OCH.sub.3                                                                               CH.sub.3                                  79     H  H       H  --  -- OCH.sub.2 CH.sub.3                                                                      NHCH.sub.3                                79     H  5-OCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 79     H  5-SCH.sub.3                                                                            H  --  -- OCH.sub.3                                                                               OCH.sub.3                                 __________________________________________________________________________

                                      TABLE 18                                     __________________________________________________________________________     General Formula 18                                                             Q      R  R.sub.1                                                                          R.sub.2                                                                           R.sub.3                                                                          W.sub.3                                                                            W.sub.4                                                                           X       Y     m.p. (°C.)                        __________________________________________________________________________     1      H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      1      CH.sub.3                                                                          H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCF.sub.2 H                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 F                                                                             OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 Cl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CF.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- SCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- NHCH.sub.3                                                                             OCH.sub.2 CH.sub.3                             1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 CH═CH                                                                    OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 C.tbd.CH                                                                     OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- cyclopropyl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- C.tbd.CH                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CHO     OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- 1,3-dioxan-                                                                            OCH.sub.3                                                              2-yl                                                   1      H  H CH.sub.3                                                                          H O   -- 2-methyl-                                                                              OCH.sub.3                                                              1,3-oxathio-                                                                   lan-2-yl                                               1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- OCH.sub. 3                                                                             OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  S  CH.sub. 3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      22     H  H CH.sub. 3                                                                         H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub. 3                                                                              CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      29(R.sub.6 =CH.sub.3 )                                                                H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       61     H  H CH.sub.3                                                                          H NCH.sub. 3                                                                         -- CH.sub.3                                                                               OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      __________________________________________________________________________

                                      TABLE 19                                     __________________________________________________________________________     General Formula 19                                                             Q      R  R.sub.1                                                                          R.sub.2                                                                           R.sub.3                                                                          W.sub.3                                                                            W.sub.4                                                                           X       Y     m.p.(°C.)                         __________________________________________________________________________     1      H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      1      CH.sub.3                                                                          H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 F                                                                             OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 Cl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CF.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- SCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- NHCH.sub.3                                                                             OCH.sub.2 CH.sub.3                             1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 CH═CH                                                                    OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 C.tbd.CH                                                                     OCH.sub.3                                      1      H  H CH.sub. 3                                                                         H O   -- cyclopropyl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- C.tbd.CH                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CHO     OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- 1,3-dioxan-                                                                            OCH.sub.3                                                              2-yl                                                   1      H  H CH.sub.3                                                                          H O   -- 2-methyl-                                                                              OCH.sub.3                                                              1,3-oxathio-                                                                   lan-2-yl                                               1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                     3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       5      H  H CH.sub. 3                                                                         H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                     16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                     19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       21     H  H CH.sub. 3                                                                         H --  -- CH.sub.3                                                                               OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub. 3                                     68     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      __________________________________________________________________________

                                      TABLE 20                                     __________________________________________________________________________     General Formula 20                                                             Q      R  R.sub.1                                                                          R.sub.2                                                                           R.sub.3                                                                          W.sub.3                                                                            W.sub.4                                                                           X       Y     m.p.(°C.)                         __________________________________________________________________________     1      H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      1      CH.sub.3                                                                          H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCF.sub.2 H                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 F                                                                             OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 Cl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CF.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- SCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- NHCH.sub.3                                                                             OCH.sub.2 CH.sub.3                             1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 CH═CH                                                                    OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 C.tbd.CH                                                                     OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- cyclopropyl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- C.tbd.CH3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CHO     OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- 1,3-dioxan-                                                                            OCH.sub.3                                                              2-yl                                                   1      H  H CH.sub.3                                                                          H O   -- 2-methyl-                                                                              OCH.sub.3                                                              1,3-oxathio-                                                                   lan-2-yl                                               1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  Cl      OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          Cl      OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- Cl      OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- Cl      OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- Cl      OCH.sub.3                                      __________________________________________________________________________

                                      TABLE 21                                     __________________________________________________________________________     General Formula 21                                                             Q      R  R.sub.1                                                                          R.sub.2                                                                           R.sub.3                                                                          W.sub.3                                                                            W.sub.4                                                                           X       Y     m.p.(°C.)                         __________________________________________________________________________     1      H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      1      CH.sub.3                                                                          H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              CH.sub.3                                       1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 F                                                                             OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CH.sub.2 Cl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CF.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- SCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- NHCH.sub.3                                                                             OCH.sub.2 CH.sub.3                             1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 CH═CH                                                                    OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- OCH.sub.2 C.tbd.CH                                                                     OCH.sub.3                                      1      H  H CH.sub. 3                                                                         H O   -- cyclopropyl                                                                            OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- C.tbd.CH                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- CHO     OCH.sub.3                                      1      H  H CH.sub.3                                                                          H O   -- 1,3-dioxan-                                                                            OCH.sub.3                                                              2-yl                                                   1      H  H CH.sub.3                                                                          H O   -- 2-methyl-                                                                              OCH.sub.3                                                              1,3-oxathio-                                                                   lan-2-yl                                               1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      1      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                     3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       3      H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      3      H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      5      H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      7      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      8      H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H O   -- OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                     16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      16     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                     19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       19     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      19     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       20     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      20     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       21     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      21     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      22     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      25     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      26     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  S  CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  S  OCH.sub.3                                                                              OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               CH.sub.3                                       27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          CH.sub.3                                                                               OCH.sub.3                                      27     H  H CH.sub.3                                                                          H --  SO.sub.2                                                                          OCH.sub.3                                                                              OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      29(R.sub.6 =CH.sub.3)                                                                 H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      55     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       56     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      56     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               CH.sub.3                                       61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- CH.sub.3                                                                               OCH.sub.3                                      61     H  H CH.sub.3                                                                          H NCH.sub.3                                                                          -- OCH.sub.3                                                                              OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       65     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      65     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       68     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      68     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               CH.sub.3                                       76     H  H CH.sub.3                                                                          H O   -- CH.sub.3                                                                               OCH.sub.3                                      76     H  H CH.sub.3                                                                          H O   -- OCH.sub.3                                                                              OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       78     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      78     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               CH.sub.3                                       79     H  H CH.sub.3                                                                          H --  -- CH.sub.3                                                                               OCH.sub.3                                      79     H  H CH.sub.3                                                                          H --  -- OCH.sub.3                                                                              OCH.sub.3                                      __________________________________________________________________________

                                      TABLE 22                                     __________________________________________________________________________     General Formula 22                                                             Q      R  R.sub.1                                                                          R.sub.3                                                                          W.sub.3                                                                            W.sub.4                                                                           X.sub.4                                                                           Y.sub.4                                                                            Z.sub.1                                                                           m.p. (°C.)                               __________________________________________________________________________     1      H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 1      H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  1      CH.sub.3                                                                          H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 1      H  H H O   -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 1      H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 1      H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  1      CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 1      H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 3      H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 3      H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  3      CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 3      H  H H --  -- CH.sub.3                                                                          OCH.sub. 3                                                                         CH                                                 5      H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 5      H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  5      CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 5      H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 7      H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 7      H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           N                                                  7      CH.sub.3                                                                          H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 7      H  H H --  S  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 7      H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 7      H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           N                                                  7      CH.sub.3                                                                          H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 7      H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 8      H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 8      H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           N                                                  8      CH.sub.3                                                                          H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 8      H  H H --  S  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 8      H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 8      H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           N                                                  8      CH.sub.3                                                                          H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 8      H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 16     H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 16     H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  16     CH.sub.3                                                                          H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 16     H  H H O   -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 16     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 16     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  16     CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 16     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 19     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 19     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  19     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 19     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 20     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 20     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  20     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 20     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 21     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 21     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  21     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 21     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 22     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 22     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  22     CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 22     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 25     H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 25     H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           N                                                  25     CH.sub.3                                                                          H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 25     H  H H --  S  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 25     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 25     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           N                                                  25     CH.sub.3                                                                          H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 25     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 26     H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 26     H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           N                                                  26     CH.sub.3                                                                          H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 26     H  H H --  S  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 26     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 26     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           N                                                  26     CH.sub.3                                                                          H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 26     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 27     H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 27     H  H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           N                                                  27     CH.sub.3                                                                          H H --  S  CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 27     H  H H --  S  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 27     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 27     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           N                                                  27     CH.sub.3                                                                          H H --  SO.sub.2                                                                          CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 27     H  H H --  SO.sub.2                                                                          CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 29 (R.sub.6 =CH.sub.3)                                                                H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 29 (R.sub.6 =CH.sub.3)                                                                H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  29 (R.sub.6 =CH.sub.3)                                                                CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 29 (R.sub.6 =CH.sub.3)                                                                H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 55     H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 55     H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  55     CH.sub.3                                                                          H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 55     H  H H O   -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 55     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 55     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  55     CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 55     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 56     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 56     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  56     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 56     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 61     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 61     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  61     CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 61     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 62     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 62     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  62     CH.sub.3                                                                          H H NCH.sub.3                                                                          -- CH.sub. 3                                                                         CH.sub.3                                                                           CH                                                 62     H  H H NCH.sub.3                                                                          -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 65     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 65     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  65     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 65     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 68     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 68     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  68     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 68     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 76     H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 76     H  H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  76     CH.sub.3                                                                          H H O   -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 76     H  H H O   -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 78     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 78     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  78     CH.sub. 3                                                                         H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 78     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 79     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 79     H  H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                                  79     CH.sub.3                                                                          H H --  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                                 79     H  H H --  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                                 __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid inert diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Active  Weight Percent*                                                        Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90      0-74     1-10                                         Oil Suspensions,                                                                              3-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts          1-25     70-99     0-5                                          Granules and Pellets                                                                         0.1-95      5-99.9  0-15                                         High Strength 90-99      0-10     0-2                                          Compositions                                                                   ______________________________________                                          *Active ingredient plus at least one of a Surfactant or a Diluent equals       100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are somtimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE 9

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                       80%                                               [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             sodium alkylnaphthalenesulfonate                                                                            2%                                                sodium ligninsulfonate       2%                                                synthetic amorphous silica   3%                                                kaolinite                    13%                                               ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.

EXAMPLE 10

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                        50%                                                 [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    sodium alkylnaphthalenesulfonate                                                                           2%                                                 low viscosity methyl cellulose                                                                             2%                                                 diatomaceous earth         46%                                                 ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE 11

    ______________________________________                                         Granule                                                                        ______________________________________                                         Wettable Powder of Example 10                                                                          5%                                                     attapulgite granules   95%                                                     (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                              ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE 12

    ______________________________________                                         Extruded Pellet                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                        25%                                                 [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    anhydrous sodium sulfate   10%                                                 crude calcium ligninsulfonate                                                                              5%                                                 sodium alkylnaphthalenesulfonate                                                                           1%                                                 calcium/magnesium bentonite                                                                               59%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

EXAMPLE 13

    ______________________________________                                         Oil Suspension                                                                 ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                       25%                                               [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             polyoxyethylene sorbitol hexaoleate                                                                          5%                                               highly aliphatic hydrocarbon oil                                                                            70%                                               ______________________________________                                    

The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.

EXAMPLE 14

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                         20%                                                [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    sodium alkylnaphthalenesulfonate                                                                           4%                                                 sodium ligninsulfonate      4%                                                 low viscosity methyl cellulose                                                                             3%                                                 attapulgite                 69%                                                ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged.

EXAMPLE 15

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                       1%                                                [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             N,N--dimethylformamide       9%                                                attapulgite granules         90%                                               (U.S.S. 20-40 sieve)                                                           ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.

EXAMPLE 16

    ______________________________________                                         Aqueous Suspension                                                             ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                          40%                                               [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    polyacrylic acid thickener  0.3%                                               dodecylphenol polyethylene glycol ether                                                                    0.5%                                               disodium phosphate            1%                                               monosodium phosphate        0.5%                                               polyvinyl alcohol           1.0%                                               water                       56.7%                                              ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.

EXAMPLE 17

    ______________________________________                                         Solution                                                                       ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                        5%                                               [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide, ammonium salt                                              water                        95%                                               ______________________________________                                    

The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use.

EXAMPLE 18

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                          0.1%                                              [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    attapulgite granules        99.9%                                              (U.S.S. 20-40 mesh)                                                            ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.

EXAMPLE 19

    ______________________________________                                         Granule                                                                        ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                       80%                                               [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             wetting agent                 1%                                               crude ligninsulfonate salt (containing                                                                      10%                                               5-20% of the natural sugars)                                                   attapulgite clay              9%                                               ______________________________________                                    

The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use.

EXAMPLE 20

    ______________________________________                                         High Strength Concentrate                                                      ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                        99%                                              [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             silica aerogel               0.5%                                              synthetic amorphous silica   0.5%                                              ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.

EXAMPLE 21

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                         90%                                                [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    dioctyl sodium sulfosuccinate                                                                             0.1%                                                synthetic fine silica      9.9%                                                ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S No. 50 screen and then packaged.

EXAMPLE 22

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                       40%                                               [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             sodium ligninsulfonate       20%                                               montmorillonite clay         40%                                               ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.

EXAMPLE 23

    ______________________________________                                         Oil Suspension                                                                 ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                        35%                                                 [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    blend of polyalcohol carboxylic                                                                            6%                                                 esters and oil soluble petroleum                                               sulfonates                                                                     xylene                     59%                                                 ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE 24

    ______________________________________                                         Dust                                                                           ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-                                                        10%                                                 [(2-oxotetrahydro-3-furanylidene)methyl]benzene-                               sulfonamide                                                                    attapulgite                10%                                                 Pyrophyllite               80%                                                 ______________________________________                                    

The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.

EXAMPLE 25

    ______________________________________                                         Emulsifiable Concentrate                                                       ______________________________________                                         N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-2-                                                       10%                                               [(2-oxotetrahydro-3-furanylidene)methyl]-3-chloro-                             benzenesulfonamide                                                             chlorobenzene                84%                                               sorbitan monostearate and polyoxyethylene                                                                    6%                                               condensates thereof                                                            ______________________________________                                    

The ingredients are combined and stirred to produce a solution which can be emulsified in water for application.

Utility

Test results indicate that the compounds of the present invention are highly active preemergent or postemergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre and/or postemergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Some of the compounds have utility for selective weed control in crops such as corn, wheat and soybeans. Alternatively, the subject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.05 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any other commercial herbicide, examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate, and bipyridylium types. The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow.

Test A

Seeds of crabgrass (Digitaria spp.), barnyardgrass (Echinochloa crusgalli), wild oats (Avena fatua), cheatgrass (Bromus secalinus), velvetleaf (Abutilon theophrasti), morningglory (Ipomoea sp.), cocklebur (Xanthium pennsylvanicum), sorghum, corn, soybean, sugarbeet, cotton, rice, wheat, and purple nutsedge (Cyperus rotundus) tubers were planted treated preemergence with the test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were treated with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols have the following meanings:

C=chlorosis or necrosis

B=burn

D=defoliation

E=emergence inhibition

G=growth retardation

H=formative effects

U=unusual pigmentation

X=axillary stimulation

S=albinism

6Y=abscised buds or flowers.

    ______________________________________                                         Compounds                                                                      ______________________________________                                          ##STR41##                                                                     Compound    R.sub.1 Z        X      Y                                          ______________________________________                                          1          H       CH       OCH.sub.3                                                                             OCH.sub.3                                   2          H       CH       OCH.sub.3                                                                             CH.sub.3                                    3          H       CH       Cl     OCH.sub.3                                   4          H       CH       CH.sub.3                                                                              CH.sub.3                                    5          H       N        OCH.sub.3                                                                             OCH.sub.3                                   6          H       N        OCH.sub.3                                                                             CH.sub.3                                    7          3-Cl    CH       OCH.sub.3                                                                             OCH.sub.3                                   8          3-Cl    CH       OCH.sub.3                                                                             CH.sub.3                                    9          3-Cl    CH       CH.sub.3                                                                              CH.sub.3                                   10          3-Cl    N        OCH.sub.3                                                                             OCH.sub.3                                  11          3-Cl    N        OCH.sub.3                                                                             CH.sub.3                                   12          H       N        OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                 ______________________________________                                          ##STR42##                                                                     Compound    R.sub.6 Z        X      Y                                          ______________________________________                                         13          CH.sub.3                                                                               CH       OCH.sub.3                                                                             OCH.sub.3                                  14          CH.sub.3                                                                               CH       CH.sub.3                                                                              OCH.sub.3                                  15          H       CH       OCH.sub.3                                                                             OCH.sub.3                                  16          H       CH       CH.sub.3                                                                              OCH.sub.3                                  ______________________________________                                          ##STR43##                                                                     Compound            Z        X      Y                                          ______________________________________                                         17                  CH       OCH.sub.3                                                                             OCH.sub. 3                                 18                  CH       CH.sub.3                                                                              OCH.sub.3                                  ______________________________________                                          ##STR44##                                                                     Compound            Z        X      Y                                          ______________________________________                                         19                  CH       CH.sub.3                                                                              OCH.sub.3                                  20                  CH       OCH.sub.3                                                                             OCH.sub.3                                  ______________________________________                                    

                                      TABLE A                                      __________________________________________________________________________             Cmpd. 1                                                                             Cmpd. 2                                                                             Cmpd. 3                                                                             Cmpd. 4                                                                             Cmpd. 5                                                                             Cmpd. 6                                                                             Cmpd. 7                                                                             Cmpd. 8                                                                             Cmpd. 9                                                                             Cmpd.                                                                               Cmpd. 11             Rate kg/ha                                                                             0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05                 __________________________________________________________________________     POSTEMERGENCE                                                                  Morningglory                                                                           10C  10C  3C,7G                                                                               2C,5G                                                                               5C,9G                                                                               9C   5C,9G                                                                               4C,9G                                                                               9C   0    3C,8G                Cocklebur                                                                              10C  9C   8C   4C,9H                                                                               5C,9G                                                                               5C,9G                                                                               5C,9G                                                                               3C,8H                                                                               8G   0    5C,9G                Velvetleaf                                                                             10C  10C  3C,8G                                                                               4C,9G                                                                               3C,7H                                                                               4C,7H                                                                               9C   4C,8G                                                                               3C,8G                                                                               0    2C,5G                Nutsedge                                                                               9C   9C   5C,9G                                                                               2C,8G                                                                               2C,6G                                                                               3C,6G                                                                               2C,8G                                                                               2C,7G                                                                               3G   0    2C,4G                Crabgrass                                                                              2C,7G                                                                               2C,7G                                                                               3G   7G   1H   0    0    4G   2C,4G                                                                               0    2G                   Barnyardgrass                                                                          9C   9C   10C  9H   2H   2H   4C,8H                                                                               8H   3C,8H                                                                               0    3H                   Cheatgrass                                                                             6C,9G                                                                               9C   4C,9G                                                                               5C,9G                                                                               0    0    9G   2C,9G                                                                               2C,9G                                                                               0    0                    Wild Oats                                                                              3C,7G                                                                               4C,9G                                                                               2C,6G                                                                               6C,9G                                                                               0    0    0    0    8G   0    0                    Wheat   8G   2C,9G                                                                               6G   9G   0    0    0    5G   0    0    0                    Corn    3U,9H                                                                               9C   7H   10C  8H   8H   0    2C,5H                                                                               3C,6H                                                                               0    3C,7H                Soybean 5C,9G                                                                               9C   4C,9G                                                                               5C,9G                                                                               9C   5C,9G                                                                               5C,9G                                                                               5C,9G                                                                               5C,9G                                                                               0    5C,9G                Rice    6C,9G                                                                               6C,9G                                                                               4C,9G                                                                               6C,9G                                                                               6G   7G   0    3G   2C,8G                                                                               0    3G                   Sorghum 4C,9H                                                                               4C,9H                                                                               3C,8H                                                                               3C,9H                                                                               2C,3H                                                                               3C,8H                                                                               2C,8H                                                                               3C,8H                                                                               3C,9H                                                                               0    3C,8H                Sugarbeets                                                                             9C   9C   4C,9H                                                                               3C,7G                                                                               9C   9C   3C,5G                                                                               1H   0    0    3C,8G                Cotton  10C  9C   2C,7G                                                                               2C,8G                                                                               2C,5G                                                                               2C,5G                                                                               3G   3C,7G                                                                               2G   0    3C,5G                Giant Foxtail                                                                  Barley                                                                         PREEMERGENCE                                                                   Morningglory                                                                           8G   9H   3C,7H                                                                               6G   8G   2C,7H                                                                               4G   8G   0    0    0                    Cocklebur                                                                              8H   9H   9H   2H   8H   8H   4G   2H   0    0    5G                   Velvetleaf                                                                             9G   9C   5C,9G                                                                               4C,8G                                                                               0    6G   8G   2H   0    0    6G                   Nutsedge                                                                               10E  10E  10E  4G   0    0    4G   0    0    0    0                    Crabgrass                                                                              3G   3C,7G                                                                               2C   4G   0    0    0    2G   0    0    0                    Barnyardgrass                                                                          2C,9H                                                                               9H   2C,5H                                                                               3C,7H                                                                               3G   3G   0    0    0    0    0                    Cheatgrass                                                                             9H   10E  3C,8G                                                                               2C,7G                                                                               4G   5G   0    0    0    0    0                    Wild Oats                                                                              2C,8G                                                                               6C,9G                                                                               2C,6G                                                                               3C,7H                                                                               0    3G   0    0    0    0    0                    Wheat   3C,9G                                                                               9C   2C,5G                                                                               2C,7G                                                                               0    0    0    0    0    0    0                    Corn    3C,9G                                                                               3C,9H                                                                               4G   2C,5G                                                                               6G   2C,7H                                                                               0    0    0    0    5G                   Soybean 9H   3C,7H                                                                               0    2C,3G                                                                               2C,2H                                                                               2C,2H                                                                               1H   2H   0    0    0                    Rice    3C,9H                                                                               4C,9H                                                                               7H   7H   8H   7H   0    0    0    0    0                    Sorghum 2C,7H                                                                               4C,9H                                                                               3C,5H                                                                               3G   2C,2H                                                                               3C,5G                                                                               0    3C,8H                                                                               0    0    0                    Sugarbeets                                                                             10E  10E  10C  9G   4C,9G                                                                               5C,9G                                                                               0    2G   0    0    5G                   Cotton  9G   8G   7G   8G   2C,8G                                                                               2C,8G                                                                               0    0    0    0    0                    Giant Foxtail                                                                  Barley                                                                         __________________________________________________________________________             Cmpd. 12                                                                             Compound 13                                                                            Compound 14                                                                            Cmpd. 15                                                                            Cmpd. 16                                                                             Cmpd. 17                                                                            Cmpd. 18                                                                             Cmpd.                                                                               Cmpd. 20              Rate kg/ha                                                                             0.05  0.05                                                                               0.01                                                                               0.05                                                                               0.01                                                                               0.05 0.05  0.05 0.05  0.05 0.05                  __________________________________________________________________________     POSTEMERGENCE                                                                  Morningglory                                                                           5C,9G 2C,5G                                                                              0   2H  0   2C,6G                                                                               2C,3H 2C,6G                                                                               2C,5G 1C   1H                    Cocklebur                                                                              4C,9H 0   0   0   0   3C,9G                                                                               3C,8H 2C,8G                                                                               2C,7G 1H   0                     Velvetleaf                                                                             4C,9G 7G  0   0   0   3C,8G                                                                               3C,6H 2C,7G                                                                               5G    7G   2H                    Nutsedge                                                                               0     4G  0   2G  0   9G   3C,7G 3C,8G                                                                               5G    0    4G                    Crabgrass                                                                              0     0   0   0   0   2G   0     0    0     3G   0                     Barnyardgrass                                                                          5C,9H 3C,8H                                                                              1H  2C,8H                                                                              2H  3C,9H                                                                               2C,8H 3C,9H                                                                               3C,9H 7H   3H                    Cheatgrass                                                                             2C,6G 5G  0   2G  0   0    0     0    0     0    0                     Wild Oats                                                                              2C,8G 0   0   2C,5G                                                                              0   0    0     0    2C    0    0                     Wheat   0     0   0   2C  0   0    0     0    0     0    0                     Corn    3C,8H 1C,5G                                                                              1H  2C,9H                                                                              0   2C,9G                                                                               3C,9H 3C,8H                                                                               3C,9H 2C,7H                                                                               5G                    Soybean 5C,9G 2H,8G                                                                              3H  3C,7G                                                                              1H  3C,9G                                                                               3C,8H 4C,9G                                                                               4C,9G 4G   3H                    Rice    9C    8G  3G  7G  0   8G   5G    9G   8G    8G   5G                    Sorghum 3C,8H 2C,7H                                                                              2G  3C,9G                                                                              4G  3C,9G                                                                               2C,8H 3C,9H                                                                               3C,7H 3C,6G                                                                               4G                    Sugarbeets                                                                             4C,8G 3C,8G                                                                              2G  4G  0   3C,5G                                                                               3C,6H 9C   3C,8G 4C,9G                                                                               3C,5G                 Cotton  2G    4G  0   0   0   3C,8H                                                                               3C,6G 3C,9G                                                                               2C,5G 2C,5G                                                                               3C,6H                 Giant Foxtail 2G  0   3G  0   3C,8G                                                                               3G    6G   4G    4G   3G                    Barley        2G  0   0   0   2C,4G                                                                               1C    0    0     0    0                     PREEMERGENCE                                                                   Morningglory                                                                           9G    0   0   0   0   2H   5G    5G   5G    5G   4G                    Cocklebur                                                                              5H    --  0   0   0   2H   4G    7G   9H    9H   8H                    Velvetleaf                                                                             5C,9G 2G  0   2H  0   3G   3G    7G   5G    3G   8G                    Nutsedge                                                                               5G    0   0   0   0   0    0     0    0     0    0                     Crabgrass                                                                              0     0   0   0   0   0    0     0    0     5G   0                     Barnyardgrass                                                                          8G    0   0   3G  0   5G   2C    7H   3G    6G   3C,3G                 Cheatgrass                                                                             3C,6G 0   0   5G  0   0    0     0    3G    4G   2G                    Wild Oats                                                                              2C,8G 0   0   5G  0   0    2C    0    0     2C   0                     Wheat   5G    0   0   3G  0   0    2G    0    0     0    0                     Corn    2C,8G 2C,7G                                                                              0   3C,9H                                                                              0   3C,5G                                                                               3C,7G 3C,7H                                                                               3C,8H 5G   3G                    Soybean 3C,7H 3G  0   2C,5G                                                                              0   3C,5H                                                                               3C,6G 3C,5G                                                                               2C,6G 4G   3G                    Rice    9H    7G  0   8H  0   3G   2C,5G 5G   7G    5G   3G                    Sorghum 2C,5G 0   0   3C,8H                                                                              0   3C,5G                                                                               3C,7G 2C,4G                                                                               2C,7G 2C,5G                                                                               4G                    Sugarbeets                                                                             5C,9G 0   0   2H  0   8G   1H    8G   8G    8G   7G                    Cotton  8G    0   0   5G  0   0    6G    7G   6G    7G   7G                    Giant Foxtail 0   0   2G  0   0    0     3G   5G    6G   3C,3G                 Barley        3G  0   5G  0   3G   3C,7G 2G   2G    4G   0                     __________________________________________________________________________ 

What is claimed is:
 1. A compound of the formula ##STR45## wherein J is ##STR46## R is H or CH₃ ; W is O or S;R₁ is H, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, halogen, nitro, C₁ -C₃ alkoxy, SO₂ NR_(a) R_(b), C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, CO₂ R_(c), amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN; R_(a) is H, C₁ -C₄ alkyl, C₂ -C₃ cyanoalkyl, OCH₃ or OC₂ H₅ ; R_(b) is H, C₁ -C₄ alkyl or C₃ -C₄ alkenyl; or R_(a) and R_(b) may be taken together as (CH₂)₃, (CH₂)₄, (CH₂)₅ or --CH₂ CH₂ OCH₂ CH₂ --; R_(c) is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, C₂ -C₄ haloalkyl, C₂ -C₃ cyanoalkyl, C₅ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or C₂ -C₄ alkoxyalkyl; R₂ is H, C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, phenyl, phenyl substituted with Cl, NO₂, CH₃ or OCH₃, C₁ -C₃ alkoxycarbonyl, C₁ -C₃ alkylsulfonyl or di(C₁ -C₂)alkylamino sulfamoyl; Q is ##STR47## n is 0, 1 or 2; R₃ is H, C₁ -C₄ alkyl, Cl or Br; R₁₀ is H or C₁ -C₄ alkyl; E is a bridge of 4 or 5 atoms, which may be substituted or unsubstituted, containing 0-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, and also containing 2-5 carbon atoms, said bridge together with one carbon attachment site forming a partially saturated or a fully unsaturated, nonaromatic 5- or 6-membered carbocyclic or heterocyclic ring, with the proviso that when E contains two atoms of oxygen or sulfur, they must be separated by at least one atom of carbon, and that oxygen and sulfur are only linked to each other if the sulfur is in the form SO or SO₂ ; in the bridging group E, sulfur may take the form of S, SO or SO₂ and one or two of the carbon atoms may be a carbonyl, thiocarbonyl or the cyclic 5- and 6-membered ketals thereof; when one of the bridging atoms is a substituted carbon, the substituents on said carbon include H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, halogen or C₁ -C₄ haloalkoxy; when the bridging atom is a nitrogen, the substituent on said nitrogen is H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₁ -C₄ alkoxyalkyl, C₂ -C₄ cyanoalkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl; A is ##STR48## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃)alkylamino; Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, Di(C₁ -C₃)alkylamino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄ haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl, C₂ -C₅ alkylthioalkyl, ##STR49## W₁ and W₂ are independently O or S; m is 2 or 3; R_(d) is H or CH₃ ; R_(e) is C₁ -C₂ alkyl; R_(f) is C₁ -C₂ alkyl; Z is CH, CCH₃, CC₂ H₅, CCl or CBr; Z₁ is N; Y₁ is O or CH₂ ; X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H; Y₃ is H or CH₃ ; X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl; and Y₄ is CH₃, OCH₃. OC₂ H₅ or Cl;and their agriculturally suitable salts; provided that (a) when W is S, then R is H, A is A-1, Z is CH and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR50## (b) when X is Cl, Br, F or I, then Z is CH and Y is OCH₃, OC₂ H₅, NH₂, NHCH₃, N(CH₃)₂, OCF₂ H or N(OCH₃)CH₃ ; (c) when X or Y is C₁ haloalkoxy, then Z is CH; (d) when the bridging group E contains a thiocarbonyl substituent, said thiocarbonyl carbon must be bonded to a nitrogen atom; (e) when J is J-2 or J-3, the substituent Q and the sulfonylurea bridge are on adjacent carbon atoms; (f) when the total number of carbon atoms in X and Y is greater than 4, then the total number of carbon atoms in R₁, R₂ and Q is less than or equal to 10; and (g) X₄ and Y₄ are not simultaneously Cl.
 2. The compounds of claim 1 where W is O; R is H; Z is CH; and Q is ##STR51## W₃ is O or NR₆ ; W₄ is O, S, SO or SO₂ ;R₄, R₅, R₆, R₇, R₈ and R₉ are independently H or C₁ -C₄ alkyl and R₁₀ is H or CH₃ ; provided that the total number of carbon atoms of R₄, R₅, R₇, R₈ and R₉ is less than or equal to
 4. 3. Compounds of claim 2 where X is CH₃, OCH₃, OC₂ H₅, Cl, Br, F, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; and Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, CH₂ OC₂ H₅, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ SC₂ H₅, cyclopropyl, ##STR52## OCF₂ H, SCF₂ H, C.tbd.CH or C.tbd.CCH₃.
 4. The compounds of claim 3 where R₁ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio.
 5. The compounds of claim 4 where R₄, R₅, R₆, R₇, R₈ and R₉ are independently H or CH₃ ; R₃ is H or C₁ -C₂ alkyl; and R₂ is H, C₁ -C₂ alkyl or CH₂ CH═CH₂.
 6. The compounds of claim 5 where A is A-1; X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃ ; Y is CH₃, OCH₃, C₂ H₅, CH₂ OCH₃, NHCH₃ or CH(OCH₃)₂ ; and Z is CH or N.
 7. The compounds of claim 6 where J is J-1 and R₁ is in the 5-position.
 8. The compounds of claim 6 where J is J-2 and R₁ is H.
 9. The compounds of claim 6 where J is J-3 and R₁ is H.
 10. The compounds of claim 6 where J is J-4 and R₁ is H.
 11. The compounds of claim 6 where J is J-5 and R₁ is H.
 12. The compounds of claim 7 where Q is Q-1.
 13. The compounds of claim 7 where Q is Q-3.
 14. The compounds of claim 7 where Q is Q-5.
 15. The compounds of claim 7 where Q is Q-7.
 16. The compounds of claim 7 where Q is Q-8.
 17. The compounds of claim 7 where Q is Q-16.
 18. The compounds of claim 7 where Q is Q-19.
 19. The compounds of claim 7 where Q is Q-22.
 20. The compounds of claim 7 where Q is Q-25.
 21. The compounds of claim 7 where Q is Q-26.
 22. The compounds of claim 7 where Q is Q-27.
 23. The compounds of claim 7 where Q is Q-55.
 24. The compounds of claim 7 where Q is Q-56.
 25. The compounds of claim 7 where Q is Q-61.
 26. The compounds of claim 7 where Q is Q-62.
 27. The compounds of claim 7 where Q is Q-68.
 28. The compounds of claim 7 where Q is Q-76.
 29. The compounds of claim 7 where Q is Q-77.
 30. The compounds of claim 7 where Q is Q-78.
 31. The compounds of claim 7 where Q is Q-79.
 32. The compounds of claim 7 where Q is Q-80.
 33. The compounds of claim 12 where W₃ is O.
 34. The compounds of claim 14 where W₃ is NH or NCH₃.
 35. The compounds of claim 15 where W₄ is S or SO₂.
 36. The compounds of claim 16 where W₄ is S or SO₂.
 37. The compounds of claim 17 where W₃ is O.
 38. The compounds of claim 19 where W₃ is NH or NCH₃.
 39. The compounds of claim 20 where W₄ is S or SO₂.
 40. The compounds of claim 21 where W₄ is S or SO₂.
 41. The compounds of claim 23 where W₃ is O.
 42. The compounds of claim 25 where W₃ is NH or NCH₃.
 43. The compounds of claim 26 where W₃ is NH or NCH₃.
 44. The compound of claim 1 which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-[(2-oxotetrahydro-3-furanylidene)methyl]benzenesulfonamide.
 45. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 1 and at least one of the following surfactant, solid or liquid diluent.
 46. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 2 and at least one of the following surfactant, solid or liquid diluent.
 47. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 3 and at least one of the following surfactant, solid or liquid diluent.
 48. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 4 and at least one of the following surfactant, solid or liquid diluent.
 49. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 5 and at least one of the following surfactant, solid or liquid diluent.
 50. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 6 and at least one of the following surfactant, solid or liquid diluent.
 51. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of a compound of claim 7 and at least one of the following surfactant, solid or liquid diluent.
 52. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 1. 53. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 2. 54. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 3. 55. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 4. 56. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 5. 57. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 6. 58. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 7. 